Publication Name	World Journal of Cardiology
Manuscript ID	52408
Country	Sweden

Received	2019-10-30 22:17
Peer-Review Started	2019-10-30 22:18
To Make the First Decision
Return for Revision	2019-12-12 04:38
Revised	2020-04-27 00:15
Second Decision	2020-05-13 08:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-05-14 21:58
Articles in Press	2020-05-14 21:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-06-26 10:14
Publish the Manuscript Online	2020-06-27 03:50

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Autonomic neurocardiogenic syndrome is stonewalled by the universal definition of myocardial infarction
Manuscript Source	Invited Manuscript
All Author List	Shams Y-Hassan
ORCID	Author(s) ORCID Number Shams Y-Hassan http://orcid.org/0000-0001-5228-9035
Funding Agency and Grant Number
Corresponding Author	Shams Y-Hassan, MBChB, MD, Doctor, Research Scientist, Coronary Artery Disease Area, Heart and Vascular Theme, Karolinska Institutet and Karolinska University Hospital, SE‐171 76, Stockholm S-141 86, Stockholm, Sweden. shams.younis-hassan@sll.se
Key Words	Universal definition; Myocardial infarction; Takotsubo; Myocardial stunning; Cardiac cramp; Autonomic neurocardiogenic syndrome
Core Tip	The fourth universal definition of myocardial infarction (MI) needs reconsideration. Type 2 MI and MI with non-obstructive coronary arteries are not evidence-based. Autonomic neuro-cardiogenic (ANCA) syndrome is the second important cause of troponin elevation after acute coronary ischemia. Troponin release in ANCA syndrome is most probably due to cardiac cramp squeezing the cardiomyocyte causing mild to moderate release of troponin from the cytosolic free pool. ANCA syndrome may occur in an acute form as in takotsubo syndrome. The syndrome may also occur in recurrent or a chronic form as in chronic heart failure with acute exacerbations, and chronic kidney diseases.
Publish Date	2020-06-27 03:50
Citation	Y-Hassan S. Autonomic neurocardiogenic syndrome is stonewalled by the universal definition of myocardial infarction. World J Cardiol 2020; 12(6): 231-247
URL	https://www.wjgnet.com/1949-8462/full/v12/i6/231.htm
DOI	https://dx.doi.org/10.4330/wjc.v12.i6.231

Full Article (PDF)	WJC-12-231.pdf
Full Article (Word)	WJC-12-231.docx
Manuscript File	52408-Review.docx
Answering Reviewers	52408-Answering-Reviewers.pdf
Audio Core Tip	52408-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	52408-Conflict-of-interest statement.pdf
Copyright License Agreement	52408-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	52408-Language certificate.pdf
Peer-review Report	52408-Peer-review(s).pdf
Scientific Misconduct Check	52408-Scientific misconduct check.pdf
Scientific Editor Work List	52408-Scientific editor work list.pdf