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3/14/2020 3:03:29 PM | Browse: 171 | Download: 205
Publication Name World Journal of Gastroenterology
Manuscript ID 52466
Country/Territory China
2019-11-05 07:46
Peer-Review Started
2019-11-05 07:46
To Make the First Decision
Return for Revision
2019-12-05 21:14
2020-01-10 08:11
Second Decision
2020-01-18 09:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-18 18:48
Articles in Press
2020-01-18 18:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-02-26 08:31
Typeset the Manuscript
2020-03-12 00:46
Publish the Manuscript Online
2020-03-14 15:03
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medical Laboratory Technology
Manuscript Type Retrospective Study
Article Title Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus
Manuscript Source Unsolicited Manuscript
All Author List Xi Cao, Qing-Hua Shang, Xiao-Ling Chi, Wei Zhang, Huan-Ming Xiao, Mi-Mi Sun, Gang Chen, Yong An, Chun-Lei Lv, Lin Wang, Yue-Min Nan, Cui-Ying Chen, Zong-Nan Tan, Xue-En Liu and Hui Zhuang
Author(s) ORCID Number
Xi Cao http://orcid.org/0000-0002-9297-0439
Qing-Hua Shang http://orcid.org/0000-0001-5439-9721
Xiao-Ling Chi http://orcid.org/0000-0003-3193-1943
Wei Zhang http://orcid.org/0000-0003-1520-7568
Huan-Ming Xiao http://orcid.org/0000-0002-8739-0720
Mi-Mi Sun http://orcid.org/0000-0002-0359-0240
Gang Chen http://orcid.org/0000-0001-5909-541X
Yong An http://orcid.org/0000-0002-2590-0916
Chun-Lei Lv http://orcid.org/0000-0003-0664-6411
Lin Wang http://orcid.org/0000-0003-0835-7410
Yue-Min Nan http://orcid.org/0000-0003-4192-099X
Cui-Ying Chen http://orcid.org/0000-0002-2136-5725
Zong-Nan Tan http://orcid.org/0000-0003-4056-9886
Xue-En Liu http://orcid.org/0000-0002-6574-4989
Hui Zhuang http://orcid.org/0000-0001-9119-6325
Funding Agency and Grant Number
Corresponding Author Xue-En Liu, MD, PhD, Academic Research, Associate Professor, Department of Microbiology and Center of Infectious Diseases, School of Basic Medical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China. xueenliu@bjmu.edu.cn
Key Words Chronic hepatitis B; Liver fibrosis; N-glycan; Multiparameter diagnostic models; Receiver operating characteristic curve analysis; Diagnostic power
Core Tip GlycoFibroTest and GlycoCirrhoTest were unsuitable for assessing fibrosis stages induced by HBV. We built three multiparameter diagnostic models based on serum N-glycans in HBV related fibrosis patients and combined them with ALT and PLT for distinguishing liver fibrosis F0-F1 from F2-F4, F0-F2 from F3-F4 and F0-F3 from F4, and the excellent diagnostic power was obtained (AUROC=0.912, 0.829 and 0.885, respectively). In addition, three combined models were verified in the validation group and diagnostic accuracies still high (AUROC=0.909, 0.858 and 0.867, respectively). Moreover, our combined models also could be used to discriminate adjacent fibrosis stages (F0-1/F2/F3/F4) (AUROC=0.917, 0.720 and 0.785, respectively).
Publish Date 2020-03-14 15:03
Citation Cao X, Shang QH, Chi XL, Zhang W, Xiao HM, Sun MM, Chen G, An Y, Lv CL, Wang L, Nan YM, Chen CY, Tan ZN, Liu XE, Zhuang H. Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus. World J Gastroenterol 2020; 26(10): 1067-1079
Url https://www.wjgnet.com/1007-9327/full/v26/i10/1067.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i10.1067
Full Article (PDF) WJG-26-1067.pdf
Full Article (Word) WJG-26-1067.docx
Manuscript File 52466-Review-Ma JY.doc
Answering Reviewers 52466-Answering reviewers.pdf
Audio Core Tip 52466-Audio core tip.mp3
Biostatistics Review Certificate 52466-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52466-Conflict-of-interest statement.pdf
Copyright License Agreement 52466-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 52466-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 52466-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 52466-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 52466-Language certificate.pdf
Supplementary Material 52466-Supplementary material.pdf
Peer-review Report 52466-Peer-review(s).pdf
Scientific Misconduct Check 52466-Scientific misconduct check.pdf
Scientific Editor Work List 52466-Scientific editor work list.pdf