| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
MANF ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Miao He, Cong Wang, Xiao-Hong Long, Jia-Jia Peng, Dong-Fang Liu, Gang-Yi Yang, Michael D Jensen and Li-Li Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81300702 |
| National Natural Science Foundation of China |
81501199 |
| Natural Science Foundation Project of Chongqing CSTC |
cstc2018jcyjAX0210 |
| Natural Science Foundation Project of Chongqing CSTC |
cstc2017jcyjAX0016 |
| the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University |
|
|
| Corresponding Author |
Li-Li Zhang, MD, PhD, Associate Professor, Doctor, Postdoc, Research Fellow, Department of Endocrinology, Chongqing Medical University, Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing 400010, Chongqing, China. zhanglili.jl@foxmail.com |
| Key Words |
Mesencephalic astrocyte-derived neurotrophic factor; Nonalcoholic fatty liver disease; Hepatic steatosis; Lipogenesis; In vitro; HepG2 |
| Core Tip |
we firstly uncover an important function of MANF in the pathogenesis of NAFLD. We find that MANF exerts significant effect on hepatic fatty metabolism. Hepatic steatosis was induced by free fatty acids. This study suggests for the first time that MANF expression was increased at early stage and gradually decreased afterwards under high FFAs stimulation in HepG2 cell. Moreover, results from gain-and-loss functional experiments showed that loss of MANF accelerated lipogenesis and aggravated HepG2 cell steatosis while MANF overexpression could inhibit lipogenesis and rescue HepG2 cell steatosis from FFAs treatment. |
| Publish Date |
2020-03-14 15:03 |
| Citation |
He M, Wang C, Long XH, Peng JJ, Liu DF, Yang GY, Jensen MD, Zhang LL. MANF ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism. World J Gastroenterol 2020; 26(10): 1029-1041 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i10/1029.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i10.1029 |
