BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
7/28/2020 2:46:56 PM | Browse: 991 | Download: 1889
 |
Received |
|
2020-01-30 13:49 |
|
Peer-Review Started |
|
2020-01-30 13:50 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2020-04-22 23:33 |
|
Revised |
|
2020-05-21 13:04 |
|
Second Decision |
|
2020-06-24 08:45 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2020-06-25 04:54 |
|
Articles in Press |
|
2020-06-25 04:54 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2020-07-03 02:23 |
|
Typeset the Manuscript |
|
2020-07-28 07:32 |
|
Publish the Manuscript Online |
|
2020-07-28 14:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Su, Yang Tai, Shi-Hang Tang, Yan-Ting Ye, Chong Zhao, Jin-Hang Gao, Bi-Guang Tuo and Cheng-Wei Tang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Fund of China |
U1702281 |
| National Natural Science Fund of China |
81670551 |
| National Natural Science Fund of China |
81873584 |
|
| Corresponding Author |
Cheng-Wei Tang, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, West China Hospital, Sichuan University, No. 37, Guo Xue Lane, Chengdu 610041, Sichuan Province, China. shcqcdmed@163.com |
| Key Words |
Liver fibrosis; Endoplasmic reticulum stress; Celecoxib; Cyclooxygenase-2; CCAAT/enhancer binding protein homologous protein; Apoptosis |
| Core Tip |
This study aims to explore the important role of celecoxib in modulating hepatocyte apoptosis during the development of liver fibrosis; to clarify that the mechanism of its regulation is mediated by endoplasmic reticulum stress, which in turn affects the progress of liver fibrosis. We concluded that therapeutic administration of celecoxib can effectively reduce hepatic apoptosis in thioacetamide-induced cirrhotic rats. The mechanism of action may be attributed to the suppression of CCAAT/enhancer binding protein homologous protein expression, which subsequently inhibited endoplasmic reticulum stress. |
| Publish Date |
2020-07-28 14:46 |
| Citation |
Su W, Tai Y, Tang SH, Ye YT, Zhao C, Gao JH, Tuo BG, Tang CW. Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats. World J Gastroenterol 2020; 26(28): 4094-4107 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i28/4094.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i28.4094 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
