ISSN |
1948-5204 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Retrospective Study |
Article Title |
Prognostic significance of systemic immune-inflammation index in patients with intrahepatic cholangiocarcinoma undergoing hepatic resection
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Hui Li, Jin-Ju Wang, Min Zhang, Bo Ren, Jia-Xin Li, Lin Xu and Hong Wu |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81972747 |
National Natural Science Foundation of China |
81872004 |
National Natural Science Foundation of China |
81800564 |
National Natural Science Foundation of China |
81770615 |
National Natural Science Foundation of China |
81700555 |
National Natural Science Foundation of China |
81672882 |
Science and Technology Support Program of Sichuan Province |
2019YFQ0001 |
Science and Technology Support Program of Sichuan Province |
2018SZ0115 |
Science and Technology Support Program of Sichuan Province |
2017SZ0003 |
Science and Technology Program of Tibet Autonomous Region |
XZ201801-GB-02 |
1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University |
ZYJC18008 |
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Corresponding Author |
Hong Wu, MD, PhD, Professor, Surgeon, Department of Liver Surgery and Liver Transplantation, West China Hospital of Sichuan University, No.37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. wuhong7801@163.com |
Key Words |
Intrahepatic cholangiocarcinoma; Systemic immune-inflammation index; Hepatectomy; Prognostic predictor; Long-term outcomes; Immunotherapy |
Core Tip |
Inflammation has been reported to play a crucial role in tumor biology. Systemic immune-inflammation index (SII), an inflammation-based index, was a composite measure of neutrophil, platelet and lymphocyte counts. No data exists until now, has evaluated its prognostic value for intrahepatc cholangiocarcinoma (ICC). This study aimed to investigate the clinical significance of preoperative SII levels in ICC patients undergoing curative resection. Patients with increased SII level were associated with worse overall survival and earlier tumor recurrence. In the future, the SII could help stratifying patients with ICC, thus guiding therapeutic choices, especially in immunotherapy. |
Publish Date |
2020-04-15 12:00 |
Citation |
Li H, Wang JJ, Zhang M, Ren B, Li JX, Xu L, Wu H. Prognostic significance of systemic immune-inflammation index in patients with intrahepatic cholangiocarcinoma undergoing hepatic resection. World J Gastrointest Oncol 2020; 12(4): 467-482 |
URL |
https://www.wjgnet.com/1948-5204/full/v12/i4/467.htm |
DOI |
https://dx.doi.org/10.4251/wjgo.v12.i4.467 |