Publication Name	World Journal of Gastroenterology
Manuscript ID	5296
Country	United Kingdom

Received	2013-08-28 11:19
Peer-Review Started	2013-08-28 14:53
To Make the First Decision	2013-09-16 20:23
Return for Revision	2013-09-17 20:08
Revised	2013-10-12 14:42
Second Decision	2013-11-18 21:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-19 12:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-14 08:23
Publish the Manuscript Online	2014-03-12 11:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice
Manuscript Source	Invited Manuscript
All Author List	Ekta K Bhardwaj, Kathryn J Else, Michael T Rogan and Geoffrey Warhurst
Funding Agency and Grant Number
Corresponding Author	Geoffrey Warhurst, PhD, Infection, Injury and Inflammation Research Group, Salford Royal NHS Foundation Trust, Clinical Sciences Building, Salford M68HD, United Kingdom. geoffrey.warhurst@manchester.ac.uk
Key Words	Helminth; Colitis; Inflammatory bowel disease; P-glycoprotein; Mdr1a
Core Tip	This study investigates the interaction between the helminth parasite Trichuris muris (T. muris) and Mdr1a-/- mice, a genetic model of inflammatory bowel disease linked to deficiency of a key transporter protein in the gut barrier. The main findings are that (1) Mdr1a mice exhibit dramatically increased susceptibility to worm infection compared to congenic controls and (2) challenge with T. muris induces severe pathological changes consistent with a marked exacerbation of colitis in this model with preliminary evidence pointing to worm persistence as a driver of this effect. These findings will be of interest in the emerging field of helminth therapy in inflammatory bowel disease (IBD) providing further evidence of the complexity of worm interaction with an IBD-susceptible host.
Publish Date	2014-03-12 11:24
Citation	Bhardwaj EK, Else KJ, Rogan MT, Warhurst G. Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice. World J Gastroenterol 2014; 20(7): 1797-1806
URL	http://www.wjgnet.com/1007-9327/full/v20/i7/1797.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i7.1797

Full Article (PDF)	WJG-20-1797.pdf
Full Article (Word)	WJG-20-1797.doc
Manuscript File	5296-Review.docx
Answering Reviewers	5296-Answering Reviewers.pdf
Copyright License Agreement	5296-Copyright Assignment.pdf
Peer-review Report	5296-Peer Review(s).pdf
Scientific Editor Work List	5296-Scientific editor work list.doc