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9/2/2014 5:02:00 PM | Browse: 972 | Download: 698
Publication Name World Journal of Gastroenterology
Manuscript ID 5296
Country/Territory United Kingdom
Received
2013-08-28 11:19
Peer-Review Started
2013-08-28 14:53
To Make the First Decision
2013-09-16 20:23
Return for Revision
2013-09-17 20:08
Revised
2013-10-12 14:42
Second Decision
2013-11-18 21:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-19 12:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-02-14 08:23
Publish the Manuscript Online
2014-03-12 11:24
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice
Manuscript Source Invited Manuscript
All Author List Ekta K Bhardwaj, Kathryn J Else, Michael T Rogan and Geoffrey Warhurst
Funding Agency and Grant Number
Corresponding Author Geoffrey Warhurst, PhD, Infection, Injury and Inflammation Research Group, Salford Royal NHS Foundation Trust, Clinical Sciences Building, Salford M68HD, United Kingdom. geoffrey.warhurst@manchester.ac.uk
Key Words Helminth; Colitis; Inflammatory bowel disease; P-glycoprotein; Mdr1a
Core Tip This study investigates the interaction between the helminth parasite Trichuris muris (T. muris) and Mdr1a-/- mice, a genetic model of inflammatory bowel disease linked to deficiency of a key transporter protein in the gut barrier. The main findings are that (1) Mdr1a mice exhibit dramatically increased susceptibility to worm infection compared to congenic controls and (2) challenge with T. muris induces severe pathological changes consistent with a marked exacerbation of colitis in this model with preliminary evidence pointing to worm persistence as a driver of this effect. These findings will be of interest in the emerging field of helminth therapy in inflammatory bowel disease (IBD) providing further evidence of the complexity of worm interaction with an IBD-susceptible host.
Publish Date 2014-03-12 11:24
Citation Bhardwaj EK, Else KJ, Rogan MT, Warhurst G. Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice. World J Gastroenterol 2014; 20(7): 1797-1806
URL http://www.wjgnet.com/1007-9327/full/v20/i7/1797.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i7.1797
Full Article (PDF) WJG-20-1797.pdf
Full Article (Word) WJG-20-1797.doc
Manuscript File 5296-Review.docx
Answering Reviewers 5296-Answering Reviewers.pdf
Copyright License Agreement 5296-Copyright Assignment.pdf
Peer-review Report 5296-Peer Review(s).pdf
Scientific Editor Work List 5296-Scientific editor work list.doc