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Articles Published Processes
1/7/2020 7:47:48 AM | Browse: 885 | Download: 1749
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Received |
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2019-11-26 18:20 |
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Peer-Review Started |
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2019-11-26 18:21 |
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To Make the First Decision |
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Return for Revision |
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2019-12-12 10:05 |
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Revised |
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2019-12-15 11:24 |
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Second Decision |
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2019-12-21 07:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-12-22 10:40 |
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Articles in Press |
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2019-12-22 10:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-12-27 18:44 |
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Typeset the Manuscript |
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2020-01-03 11:18 |
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Publish the Manuscript Online |
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2020-01-07 07:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Feedback regulation between phosphatidylinositol-3,4,5-trisphosphate dependent rac exchange factor 1 and transforming growth factor β1 and prognostic value in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi Shao and Zhi-Ming Chen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhi-Ming Chen, MSc, Doctor, Doctor, Department of Chemotherapy, Affiliated Hospital of Nantong University, No. 10, Xisi Road, Nantong 226001, Jiangsu Province, China, Nantong 226001, Jiangsu Province, China. czm614@163.com |
| Key Words |
Phosphatidylinositol-3,4,5-trisphosphate dependent rac exchange factor 1; Gastric cancer; High expression; Poor prognosis; Metastasis; Transforming growth factor β1 pathway |
| Core Tip |
In this study, we fully identified the overexpression of phosphatidylinositol-3,4,5-trisphosphate dependent rac exchange factor 1 (PREX1) in gastric cancer, and the positive correlation with the gastric cancer progression. High PREX1 expression predicts poor prognosis in the specific intestinal-type gastric cancer patients. PREX1 has a closely involved with cell adhesion, and PREX1 has a positive feedback loop regulation with transforming growth factor β1 pathway to promote the metastasis of gastric cancer cells. PREX1 may be a novel target for the drug development of gastric cancer, and PREX1 also acts as a predictor for prognosis of intestinal-specific gastric cancer. |
| Publish Date |
2020-01-07 07:47 |
| Citation |
Shao Q, Chen ZM. Feedback regulation between phosphatidylinositol-3,4,5-trisphosphate dependent rac exchange factor 1 and transforming growth factor β1 and prognostic value in gastric cancer. World J Gastroenterol 2020; 26(1): 21-34 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i1/21.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i1.21 |
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