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Articles Published Processes
9/21/2020 4:02:08 PM | Browse: 713 | Download: 1371
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Received |
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2019-11-28 20:02 |
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Peer-Review Started |
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2019-11-28 20:02 |
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To Make the First Decision |
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2020-01-14 02:04 |
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Return for Revision |
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2020-01-14 07:43 |
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Revised |
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2020-06-29 01:36 |
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Second Decision |
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2020-08-25 02:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-08-26 04:50 |
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Articles in Press |
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2020-08-26 04:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-08-28 18:17 |
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Typeset the Manuscript |
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2020-09-17 14:24 |
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Publish the Manuscript Online |
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2020-09-21 16:02 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
N-acetylcysteine and glycyrrhizin combination: Benefit outcome in a murine model of acetaminophen-induced liver failure
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| Manuscript Source |
Invited Conference Manuscripts |
| All Author List |
Charlotte Minsart, Sandrine Rorive, Arnaud Lemmers, Eric Quertinmont and Thierry Gustot |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Charlotte Minsart, PhD, Research Scientist, Laboratory of Experimental Gastroenterology, Erasme Hospital, Université Libre de Bruxelles, 808, Route de Lennik, Brussels 1070, Belgium. charlotte.minsart@erasme.ulb.ac.be |
| Key Words |
Acetaminophen; Acute liver injury; Glycyrrhizin; N-acetylcysteine; N-acetylcysteine/glycyrrhizin combination; Murine model |
| Core Tip |
Acetaminophen overdose is the most common cause of drug-induced liver failure in the developed countries. Substantial progress has been made in understanding the mechanism of hepatocellular injury, but N-acetylcysteine remains the only effective treatment despite its short therapeutic window. We present here our first results on the combination of N-acetylcysteine and glycyrrhizin in a murine model of acetaminophen-induced liver injury. Acetaminophen toxicity was induced by an intraperitoneal dose of 500 mg/kg. Hepatotoxicity was assessed by biochemical and histopathological analyses. Survival rates were also compared. Our results suggest, for the first time, that the combination of N-acetylcysteine and glycyrrhizin may be effective in preventing acetaminophen-induced liver injury. |
| Publish Date |
2020-09-21 16:02 |
| Citation |
Minsart C, Rorive S, Lemmers A, Quertinmont E, Gustot T. N-acetylcysteine and glycyrrhizin combination: Benefit outcome in a murine model of acetaminophen-induced liver failure. World J Hepatol 2020; 12(9): 596-618 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i9/596.htm |
| DOI |
https://dx.doi.org/ 10.4254/wjh.v12.i9.596 |
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