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Articles Published Processes
4/7/2020 2:46:34 PM | Browse: 932 | Download: 1687
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Received |
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2019-12-02 03:11 |
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Peer-Review Started |
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2019-12-02 03:12 |
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To Make the First Decision |
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Return for Revision |
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2019-12-12 02:25 |
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Revised |
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2020-02-20 01:20 |
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Second Decision |
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2020-03-08 12:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-03-09 07:08 |
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Articles in Press |
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2020-03-09 07:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-03-19 20:42 |
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Typeset the Manuscript |
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2020-04-06 00:54 |
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Publish the Manuscript Online |
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2020-04-07 14:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Calpain-2 activity promotes aberrant endoplasmic reticulum stress-related apoptosis in hepatocytes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ru-Jia Xie, Xiao-Xia Hu, Lu Zheng, Shuang Cai, Yu-Si Chen, Yi Yang, Ting Yang, Bing Han and Qin Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81560105 |
| the Department of Science and Technology of Guizhou Province |
LH (2014) 7074 |
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| Corresponding Author |
Bing Han, MD, Academic Research, Department of Pathophysiology, College of Basic Medical Sciences, Guizhou Medical University, Dongqing Road, Guiyang 550025, Guizhou Province, China. 47569390@qq.com |
| Key Words |
Calcium; Calpain-2; Caspase-12; Endoplasmic reticulum stress; Apoptosis; Hepatocyte |
| Core Tip |
Hepatocyte apoptosis is associated with many liver diseases. During the process of apoptosis, calpain-2 can cleave several apoptosis-related proteins. However, the regulatory mechanisms by which calpain-2 regulates the endoplasmic reticulum (ER) stress-mediated hepatocyte apoptosis remain unclear. In this study, the effect of calpain-2 on ER stress-mediated hepatocyte apoptosis and underlying regulatory mechanisms was investigated. Our data indicate that calpain-2 is crucial for the aberrant ER stress-induced apoptosis of hepatocytes and may be a new therapeutic target for liver diseases. |
| Publish Date |
2020-04-07 14:46 |
| Citation |
Xie RJ, Hu XX, Zheng L, Cai S, Chen YS, Yang Y, Yang T, Han B, Yang Q. Calpain-2 activity promotes aberrant endoplasmic reticulum stress-related apoptosis in hepatocytes. World J Gastroenterol 2020; 26(13): 1450-1462 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i13/1450.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i13.1450 |
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