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Publication Name World Journal of Gastroenterology
Manuscript ID 53130
Country/Territory United States
2019-12-05 23:41
Peer-Review Started
2019-12-05 23:41
To Make the First Decision
Return for Revision
2019-12-30 17:18
2020-02-09 23:21
Second Decision
2020-02-14 13:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-02-14 22:22
Articles in Press
2020-02-14 22:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-03-04 09:40
Publish the Manuscript Online
2020-03-06 10:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Review
Article Title Role of alcohol in pathogenesis of hepatitis B virus infection
Manuscript Source Invited Manuscript
All Author List Murali Ganesan, Allison Eikenberry, Larisa Y Poluektova, Kusum K Kharbanda and Natalia A Osna
Author(s) ORCID Number
Murali Ganesan http://orcid.org/0000-0002-2981-568X
Allison Eikenberry http://orcid.org/0000-0001-6469-7036
Larisa Y Poluektova http://orcid.org/0000-0001-7339-8732
Kusum K Kharbanda http://orcid.org/0000-0001-7759-8889
Natalia A Osna http://orcid.org/0000-0001-7498-0556
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health, NIAAA K01AA026864
Corresponding author Murali Ganesan, PhD, Assistant Professor, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE 68198, United States. murali.ganesan@unmc.edu
Key Words Hepatitis B virus; Alcohol; Immunity; Oxidative stress; Liver disease;
Core Tip In this review, we discussed the literature and some of our recent findings on the combined effects of alcohol and hepatitis B virus (HBV)-infection in the progression of liver diseases, such as steatosis, fibrosis, cirrhosis and hepatocellular carcinoma. Worldwide, 1.5 billion people had chronic liver disease in 2017, most commonly resulting from HBV (29%) and alcoholic liver disease (2%). Clinical evidence supports the synergistic effect of alcohol and HBV- infection on progression of end-stage liver diseases. The possible mechanisms for the chronic liver diseases induced by the combination of alcohol and HBV-infection are increased HBV replication, oxidative stress, cell organelles stress [such as endoplasmic reticulum and Golgi stress] and importantly, weakened immune responses. Better understanding of these mechanisms will improve the treatment options for the HBV-alcoholic patients.
Publish Date 2020-03-06 10:54
Citation Ganesan M, Eikenberry A, Poluektova LY, Kharbanda KK, Osna NA. Role of alcohol in pathogenesis of hepatitis B virus infection. World J Gastroenterol 2020; 26(9): 883-903
Url https://www.wjgnet.com/1007-9327/full/v26/i9/883.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i9.883
Full Article (PDF) WJG-26-883.pdf
Full Article (Word) WJG-26-883.docx
Manuscript File 53130-Review.docx
Answering Reviewers 53130-Answering reviewers.pdf
Audio Core Tip 53130-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 53130-Conflict-of-interest statement.pdf
Copyright License Agreement 53130-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53130-Grant application form(s).pdf
Peer-review Report 53130-Peer-review(s).pdf
Scientific Misconduct Check 53130-Scientific misconduct check.pdf
Scientific Editor Work List 53130-Scientific editor work list.pdf