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Articles Published Processes
3/6/2020 10:54:23 AM | Browse: 1064 | Download: 1494
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Received |
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2019-12-05 23:41 |
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Peer-Review Started |
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2019-12-05 23:41 |
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To Make the First Decision |
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Return for Revision |
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2019-12-30 17:18 |
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Revised |
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2020-02-09 23:21 |
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Second Decision |
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2020-02-14 13:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-02-14 22:22 |
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Articles in Press |
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2020-02-14 22:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-03-04 09:40 |
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Publish the Manuscript Online |
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2020-03-06 10:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Review |
| Article Title |
Role of alcohol in pathogenesis of hepatitis B virus infection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Murali Ganesan, Allison Eikenberry, Larisa Y Poluektova, Kusum K Kharbanda and Natalia A Osna |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health, NIAAA |
K01AA026864 |
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| Corresponding Author |
Murali Ganesan, PhD, Assistant Professor, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE 68198, United States. murali.ganesan@unmc.edu |
| Key Words |
Hepatitis B virus; Alcohol; Immunity; Oxidative stress; Liver disease; |
| Core Tip |
In this review, we discussed the literature and some of our recent findings on the combined effects of alcohol and hepatitis B virus (HBV)-infection in the progression of liver diseases, such as steatosis, fibrosis, cirrhosis and hepatocellular carcinoma. Worldwide, 1.5 billion people had chronic liver disease in 2017, most commonly resulting from HBV (29%) and alcoholic liver disease (2%). Clinical evidence supports the synergistic effect of alcohol and HBV- infection on progression of end-stage liver diseases. The possible mechanisms for the chronic liver diseases induced by the combination of alcohol and HBV-infection are increased HBV replication, oxidative stress, cell organelles stress [such as endoplasmic reticulum and Golgi stress] and importantly, weakened immune responses. Better understanding of these mechanisms will improve the treatment options for the HBV-alcoholic patients. |
| Publish Date |
2020-03-06 10:54 |
| Citation |
Ganesan M, Eikenberry A, Poluektova LY, Kharbanda KK, Osna NA. Role of alcohol in pathogenesis of hepatitis B virus infection. World J Gastroenterol 2020; 26(9): 883-903 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i9/883.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i9.883 |
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