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Articles Published Processes
7/26/2020 8:24:58 AM | Browse: 650 | Download: 1167
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Received |
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2020-01-20 11:58 |
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Peer-Review Started |
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2020-01-20 11:58 |
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To Make the First Decision |
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Return for Revision |
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2020-03-24 15:24 |
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Revised |
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2020-04-04 01:11 |
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Second Decision |
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2020-05-15 10:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-17 01:38 |
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Articles in Press |
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2020-05-17 01:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-05-21 23:08 |
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Typeset the Manuscript |
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2020-07-20 02:43 |
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Publish the Manuscript Online |
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2020-07-26 08:24 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Bone marrow mesenchymal stem cells induce M2 microglia polarization through PDGF-AA/MANF signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fan Yang, Wen-Bin Li, Ye-Wei Qu, Jin-Xing Gao, Yu-Shi Tang, Dong-Jie Wang and Yu-Jun Pan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences |
SKLN-201402 |
| State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences |
SKLN-201801 |
| Foundation for Returned Overseas Chinese Scholars of Heilongjiang Province |
LC201040 |
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| Corresponding Author |
Yu-Jun Pan, PhD, Chief Doctor, Professor, Department of Neurology, The First Clinical College of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. yujunpan@ems.hrbmu.edu.cn |
| Key Words |
Mesencephalic astrocyte–derived neurotrophic factor; Bone marrow mesenchymal stem cell; Microglia/macrophage polarization; Endoplasmic reticulum stress; Cerebral ischemia/reperfusion injury; |
| Core Tip |
Induction of M2 microglia/macrophage polarization may contribute to the mechanisms underlying the neuroprotective effect of bone marrow mesenchymal stem cells (BMSCs) in treating stroke. This is one of the few known studies exploring the soluble mediators responsible for interactions between BMSCs and microglia/macrophages. We demonstrated that BMSCs-mediated MANF paracrine signaling, in particular the PDGF-AA/miR-30a*/XBP1/MANF pathway, was involved in BMSCs-induced M2 phenotype polarization. Therefore, this novel molecular mechanism of BMSCs-based immunomodulatory effect on microglia/macrophages may be a novel promising therapeutic strategy for treatment of ischemic stroke. |
| Publish Date |
2020-07-26 08:24 |
| Citation |
Yang F, Li WB, Qu YW, Gao JX, Tang YS, Wang DJ, Pan YJ. Bone marrow mesenchymal stem cells induce M2 microglia polarization through PDGF-AA/MANF signaling. World J Stem Cells 2020; 12(7): 633-658 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i7/633.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i7.633 |
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