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7/21/2020 1:23:48 PM | Browse: 92 | Download: 135
Publication Name World Journal of Gastroenterology
Manuscript ID 53304
Country/Territory China
Received
2019-12-15 06:14
Peer-Review Started
2019-12-15 06:14
To Make the First Decision
Return for Revision
2020-04-01 03:32
Revised
2020-05-15 13:05
Second Decision
2020-06-30 09:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-06-30 19:33
Articles in Press
2020-06-30 19:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-07-07 03:30
Typeset the Manuscript
2020-07-20 08:33
Publish the Manuscript Online
2020-07-21 13:23
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Hepatic microenvironment underlies fibrosis in chronic hepatitis B patients
Manuscript Source Invited Manuscript
All Author List Qun-Yan Yao, Ya-Dong Feng, Pei Han, Feng Yang and Guang-Qi Song
ORCID
Author(s) ORCID Number
Qun-Yan Yao http://orcid.org/0000-0003-3586-1911
Ya-Dong Feng http://orcid.org/0000-0003-4401-6808
Pei Han http://orcid.org/0000-0003-0983-2471
Feng Yang http://orcid.org/0000-0001-8790-6072
Guang-Qi Song http://orcid.org/0000-0002-2409-0771
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation for the Youth of China 81500460
National Natural Science Foundation for the Youth of China 81700550
Corresponding Author Guang-Qi Song, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, Shanghai 200032, China. song_guangqi@fudan.edu.cn
Key Words Microenvironment; Liver fibrosis; Chronic hepatitis B; Human stellate cell; Interleukin-1β;
Core Tip We partially profiled the microenvironment factors in hepatitis B virus (HBV) infected patients. In vitro, we stimulated hepatic stellate cell line LX-2 with different growth factors, cytokines or the combination. Our study demonstrated that the hepatic microenvironment involving crosstalk of profibrotic and proinflammatory factors in the hepatitis patients underlies fibrosis. Treating the stellate cells by combining interleukin-1β and transforming growth factor-β1 may serve as an in vitro model for fibrotic HBV infected patients better recapitulating the liver microenvironment.
Publish Date 2020-07-21 13:23
Citation Yao QY, Feng YD, Han P, Yang F, Song GQ. Hepatic microenvironment underlies fibrosis in chronic hepatitis B patients. World J Gastroenterol 2020; 26(27): 3917-3928
Url https://www.wjgnet.com/1007-9327/full/v26/i27/3917.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i27.3917
Full Article (PDF) WJG-26-3917.pdf
Full Article (Word) WJG-26-3917.docx
Manuscript File 53304-Review-Webster J.docx
Answering Reviewers 53304-Answering reviewers.pdf
Audio Core Tip 53304-Audio core tip.m4a
Biostatistics Review Certificate 53304-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53304-Conflict-of-interest statement.pdf
Copyright License Agreement 53304-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53304-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 53304-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 53304-Language certificate.pdf
Supplementary Material 53304-Supplementary material.pdf
Peer-review Report 53304-Peer-review(s).pdf
Scientific Misconduct Check 53304-Bing-Wang J-1.png
Scientific Misconduct Check 53304-Bing-Liu M-2.PNG
Scientific Misconduct Check 53304-Scientific misconduct check.pdf
Scientific Editor Work List 53304-Scientific editor work list.pdf