BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
7/21/2020 1:23:48 PM | Browse: 972 | Download: 1889
 |
Received |
|
2019-12-15 06:14 |
 |
Peer-Review Started |
|
2019-12-15 06:14 |
 |
To Make the First Decision |
|
|
 |
Return for Revision |
|
2020-04-01 03:32 |
 |
Revised |
|
2020-05-15 13:05 |
 |
Second Decision |
|
2020-06-30 09:21 |
 |
Accepted by Journal Editor-in-Chief |
|
|
 |
Accepted by Executive Editor-in-Chief |
|
2020-06-30 19:33 |
 |
Articles in Press |
|
2020-06-30 19:33 |
 |
Publication Fee Transferred |
|
|
 |
Edit the Manuscript by Language Editor |
|
2020-07-07 03:30 |
 |
Typeset the Manuscript |
|
2020-07-20 08:33 |
 |
Publish the Manuscript Online |
|
2020-07-21 13:23 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Hepatic microenvironment underlies fibrosis in chronic hepatitis B patients
|
Manuscript Source |
Invited Manuscript |
All Author List |
Qun-Yan Yao, Ya-Dong Feng, Pei Han, Feng Yang and Guang-Qi Song |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation for the Youth of China |
81500460 |
National Natural Science Foundation for the Youth of China |
81700550 |
|
Corresponding Author |
Guang-Qi Song, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, Shanghai 200032, China. song_guangqi@fudan.edu.cn |
Key Words |
Microenvironment; Liver fibrosis; Chronic hepatitis B; Human stellate cell; Interleukin-1β; |
Core Tip |
We partially profiled the microenvironment factors in hepatitis B virus (HBV) infected patients. In vitro, we stimulated hepatic stellate cell line LX-2 with different growth factors, cytokines or the combination. Our study demonstrated that the hepatic microenvironment involving crosstalk of profibrotic and proinflammatory factors in the hepatitis patients underlies fibrosis. Treating the stellate cells by combining interleukin-1β and transforming growth factor-β1 may serve as an in vitro model for fibrotic HBV infected patients better recapitulating the liver microenvironment. |
Publish Date |
2020-07-21 13:23 |
Citation |
Yao QY, Feng YD, Han P, Yang F, Song GQ. Hepatic microenvironment underlies fibrosis in chronic hepatitis B patients. World J Gastroenterol 2020; 26(27): 3917-3928 |
URL |
https://www.wjgnet.com/1007-9327/full/v26/i27/3917.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v26.i27.3917 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345