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Articles Published Processes
5/27/2020 9:55:16 AM | Browse: 868 | Download: 2225
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Received |
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2019-12-18 05:24 |
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Peer-Review Started |
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2019-12-18 05:27 |
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To Make the First Decision |
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Return for Revision |
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2020-01-06 22:00 |
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Revised |
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2020-03-13 18:17 |
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Second Decision |
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2020-04-15 08:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-04-19 00:00 |
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Articles in Press |
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2020-04-19 00:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-04-25 22:50 |
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Typeset the Manuscript |
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2020-05-13 00:03 |
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Publish the Manuscript Online |
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2020-05-27 09:55 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of cholesterol on in vitro cultured interstitial Cajal-like cells isolated from guinea pig gallbladders
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Bei-Bei Fu, Jin-Huang Xu, Shuo-Dong Wu and Ying Fan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81000183 |
| Natural Science Foundation of Liaoning Province |
20180550125 |
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| Corresponding Author |
Ying Fan, MD, PhD, Doctor, Doctor, Professor, Department of General Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. coolingpine78@163.com |
| Key Words |
Interstitial Cajal-like cells; Cholesterol; Apoptosis; c-Kit; ; |
| Core Tip |
Interstitial Cajal-like cells (ICLCs) in the gallbladder have been reported to play an important role in the regulation of gallbladder motility. Loss and/or dysfunction of ICLCs may contribute to motion abnormality of gallbladder and promote cholesterol gallstone formation. Absorption of supersaturated cholesterol in bile by the gallbladder wall might be the cause of reductions in gallbladder ICLCs. This study evaluated the the effect of cholesterol on the proliferation and apoptosis of ICLCs from guinea pig gallbladders. We found high concentrations of cholesterol can inhibit the proliferation of ICLCs and promote apoptosis. This decrease in the ICLC proliferation rate might be caused by the inhibition of the stem cell factor /c-kit signaling pathway. ICLCs may serve as alternative treatment target for preventing cholesterol gallstones. |
| Publish Date |
2020-05-27 09:55 |
| Citation |
Fu BB, Huang XJ, Wu SD, Fan Y. Effect of cholesterol on in vitro cultured interstitial Cajal-like cells isolated from guinea pig gallbladders. World J Gastrointest Surg 2020; 12(5): 226-235 |
| URL |
https://www.wjgnet.com/1948-9366/full/v12/i5/226.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v12.i5.226 |
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