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Articles Published Processes
6/24/2020 10:31:56 AM | Browse: 775 | Download: 1247
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Received |
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2019-12-20 01:36 |
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Peer-Review Started |
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2019-12-18 08:28 |
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To Make the First Decision |
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Return for Revision |
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2020-04-02 22:14 |
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Revised |
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2020-05-11 03:05 |
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Second Decision |
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2020-06-03 09:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-06-03 18:00 |
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Articles in Press |
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2020-06-03 18:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-06-12 08:11 |
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Publish the Manuscript Online |
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2020-06-24 10:31 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Preoperative markers for the prediction of high-risk features in endometrial cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pinyada Panyavaranant and Tarinee Manchana |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tarinee Manchana, MD, Associate Professor, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, 1873, Rama IV Road, Patumwan, Bangkok 10330, Thailand. tarinee.m@chula.ac.th |
| Key Words |
CA125; Endometrial cancer; HE4; Prognostic factor; -; - |
| Core Tip |
Standard surgical treatment in endometrial cancer consists of hysterectomy with bilateral salpingo-oophorectomy. Node dissection is performed in selected patients with high-risk features such as grade 3 tumors, large tumor sizes (more than 2 cm), deep myometrial invasion (more than 50%), lymphovascular space invasion, cervical involvement, and extrauterine involvement. Preoperative cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) levels were significantly elevated in clinical stage 1 postmenopausal endometrial cancer patients with these high-risk features and an increased risk of upstaging. CA125 levels above 20 U/mL and HE4 levels above 113 pmol/L were used as the optimal cut-off values for the prediction of high-risk features, and they were also shown to be poor prognostic factors. Preoperative CA125 and HE4 may be an acceptable screening test for general gynecologists to consider the referral of these high-risk patients to gynecologic oncologists to perform complete surgical staging. |
| Publish Date |
2020-06-24 10:31 |
| Citation |
Panyavaranant P, Manchana T. Preoperative markers for the prediction of high-risk features in endometrial cancer. World J Clin Oncol 2020; 11(6): 378-388 |
| URL |
https://www.wjgnet.com/2218-4333/full/v11/i6/378.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v11.i6.378 |
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