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Articles Published Processes
9/3/2014 5:13:00 PM | Browse: 1017 | Download: 1112
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Received |
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2013-08-31 19:06 |
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Peer-Review Started |
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2013-09-02 16:52 |
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To Make the First Decision |
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2013-09-27 16:58 |
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Return for Revision |
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2013-09-29 10:23 |
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Revised |
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2013-10-30 21:15 |
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Second Decision |
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2013-12-05 19:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-12-06 11:56 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-01-08 19:50 |
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Publish the Manuscript Online |
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2014-01-26 20:08 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Intra-gastric triacetin alters upper gastrointestinal motility in conscious dogs
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Manuscript Source |
Invited Manuscript |
All Author List |
Kazumasa Oosaka, Masaaki Tokuda and Naohiro Furukawa |
Funding Agency and Grant Number |
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Corresponding Author |
Dr. Kazumasa Oosaka, Research and Development Department, Fushimi Pharmaceutical Co., Ltd., Nakatsu-cho 1676, Marugame, Kagawa 7638605, Japan. ohsaka@fushimi.co.jp
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Key Words |
Gastrointestinal motility; Barostat; Proximal gastric relaxation; Short-chain triglycerides |
Core Tip |
Intra-gastric infusion of short-chain triglycerides, such as triacetin, has been shown to delay gastric emptying in conscious dogs, but the influence on upper gastrointestinal motility is unknown. The current study examined time-dependent changes in motility following intra-gastric triacetin administration at various doses in conscious dogs and evaluated the effects of a fasted vs fed state. Compared to infusion of water (vehicle) alone, the 1.0% and 2.0% triacetin doses induced a significant increase in the proximal stomach receptive volume, a temporary inhibition of gastric antral contractions, and an increase in the duodenal contractions in fasted dogs.
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Publish Date |
2014-01-26 20:08 |
Citation |
Oosaka K, Tokuda M, Furukawa N. Intra-gastric triacetin alters upper gastrointestinal motility in conscious dogs. World J Gastroenterol 2014; 20(4): 1054-1060 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i4/1054.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i4.1054 |
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