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Articles Published Processes
8/5/2020 9:37:50 AM | Browse: 644 | Download: 1150
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Received |
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2020-01-14 14:30 |
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Peer-Review Started |
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2020-01-14 14:31 |
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To Make the First Decision |
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Return for Revision |
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2020-04-11 13:49 |
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Revised |
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2020-05-11 11:02 |
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Second Decision |
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2020-07-16 10:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-07-19 21:52 |
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Articles in Press |
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2020-07-19 21:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-08-03 00:56 |
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Publish the Manuscript Online |
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2020-08-05 09:37 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Shared changes in angiogenic factors across gastrointestinal vascular conditions: A pilot study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Atiyekeogbebe R Douglas, Grainne Holleran, Sinead M Smith and Deirdre McNamara |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Atiyekeogbebe R Douglas, MSc, Research Scientist, TAGG Research Centre, Trinity Centre, Tallaght Hospital, School of Medicine, Trinity College Dublin, College Green, Dublin D24, Ireland. douglaar@tcd.ie |
| Key Words |
Gastric antral vascular ectasia; Portal hypertensive gastropathy; Angiodysplasia; Angiopoietins; Angiogenic factors; Recurrent bleeding |
| Core Tip |
This is the first study to look at key angiogenic factors across several distinct intestinal vascular disorders. Our novel study suggests a common alteration in Angiopoietin 1 (Ang-1) levels, a vascular factor associated with vessel stabilization and maturation, across a variety of gastrointestinal vascular disorders. VEGF appears not to play a significant role in these conditions. Serum elevation in Ang-2 levels and lower than normal Ang-1 levels are associated with clinically significant disease and warrant further investigation as potential biomarkers and therapeutic targets. This offers a potential final common pathway which could be of use diagnostically and therapeutically across several vascular conditions. |
| Publish Date |
2020-08-05 09:37 |
| Citation |
Douglas AR, Holleran G, Smith SM, McNamara D. Shared changes in angiogenic factors across gastrointestinal vascular conditions: A pilot study. World J Gastrointest Pharmacol Ther 2020; 11(3): 40-47 |
| URL |
https://www.wjgnet.com/2150-5349/full/v11/i3/40.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v11.i3.40 |
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