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Articles Published Processes
6/21/2020 2:15:44 PM | Browse: 1073 | Download: 1178
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Received |
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2019-12-23 15:01 |
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Peer-Review Started |
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2019-12-23 15:02 |
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To Make the First Decision |
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Return for Revision |
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2020-03-24 17:27 |
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Revised |
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2020-04-07 23:06 |
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Second Decision |
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2020-06-04 08:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-06-04 17:19 |
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Articles in Press |
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2020-06-04 17:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-06-18 10:11 |
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Publish the Manuscript Online |
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2020-06-21 14:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Review of primary sclerosing cholangitis with increased IgG4 levels
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Charis D Manganis, Roger W Chapman and Emma L Culver |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute of Health Research Biomedical Research Centre |
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| Oxfordshire Health Service Research Committee |
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| Corresponding Author |
Emma L Culver, BSc, DPhil, MBChB, MRCP, Doctor, Doctor, Senior Lecturer, Translational Gastroenterology Department and NIHR Biomedical Research Centre, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, United Kingdom. emma.culver@nhs.net |
| Key Words |
Primary sclerosing cholangitis; IgG4; IgG4-related disease; IgG4-related sclerosing cholangitis; ; |
| Core Tip |
Elevated serum IgG4 titres and/or abundant IgG4-positive plasma cell infiltrates in the liver and bile ducts are present in up-to one-quarter of patients with primary sclerosing cholangitis (PSC). It should be distinguished from IgG4-related sclerosing cholangitis. PSC with high IgG4 have a different clinical phenotype to those with normal IgG4, with higher bilirubin and alkaline phosphatase, higher PSC Mayo Risk Score, more advanced liver disease, shorter time to liver transplantation, more aggressive colitis and shorter time to colectomy. Corticosteroids may provide biochemical improvement but rarely results in cholangiographic resolution. Concerns include steroid toxicity, infection and disease progression in those with advanced cirrhosis. |
| Publish Date |
2020-06-21 14:15 |
| Citation |
Manganis CD, Chapman RW, Culver EL. Review of primary sclerosing cholangitis with increased IgG4 levels. World J Gastroenterol 2020; 26(23): 3126-3144 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i23/3126.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i23.3126 |
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