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Articles Published Processes
5/14/2020 10:09:31 AM | Browse: 871 | Download: 1280
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Received |
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2019-12-24 14:49 |
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Peer-Review Started |
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2019-12-24 14:51 |
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To Make the First Decision |
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Return for Revision |
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2020-02-20 05:01 |
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Revised |
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2020-03-18 20:46 |
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Second Decision |
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2020-03-25 07:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-03-26 13:40 |
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Articles in Press |
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2020-03-26 13:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-05-08 08:56 |
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Publish the Manuscript Online |
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2020-05-14 10:09 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Anesthesiology |
| Manuscript Type |
Minireviews |
| Article Title |
Neuroendocrine, epigenetic, and intergenerational effects of general anesthetics
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anatoly E Martynyuk, Ling-Sha Ju, Timothy E Morey and Jia-Qiang Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
R01NS091542 |
| National Natural Science Foundation of China |
81771149 |
| National Natural Science Foundation of China |
U1704165 |
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| Corresponding Author |
Anatoly E Martynyuk, DSc, PhD, Professor, Department of Anesthesiology and the McKnight Brain Institute, University of Florida College of Medicine, 1600 SW Archer Road, PO Box 100254, Gainesville, FL 32610, United States. amartynyuk@anest.ufl.edu |
| Key Words |
Brain; General anesthetic; Sevoflurane; Corticosterone; Cortisol; Histone acetylation |
| Core Tip |
The GABAergic general anesthetics may act as stressors and endocrine disruptors in neonates and young adults. They may induce two distinct types of long-term adverse effects: neuroendocrine effects (the somatic effects) and epigenetic reprogramming of germ cells (the germ cell effects). The latter may pass neurobehavioral abnormalities to male offspring. Compared to the somatic cells, the germ cells may be more sensitive to the deleterious effects of general anesthetics, raising the possibility that the offspring may be affected even when levels of anesthesia are not harmful to the exposed parents. Further rigorous experimental testing of all these possibilities is required. |
| Publish Date |
2020-05-14 10:09 |
| Citation |
Martynyuk AE, Ju LS, Morey TE, Zhang JQ. Neuroendocrine, epigenetic, and intergenerational effects of general anesthetics. World J Psychiatr 2020; 10(5): 81-94 |
| URL |
https://www.wjgnet.com/2220-3206/full/v10/i5/81.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v10.i5.81 |
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