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Articles Published Processes
3/24/2020 5:16:35 AM | Browse: 902 | Download: 1573
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Received |
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2019-12-24 07:18 |
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Peer-Review Started |
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2019-12-23 16:49 |
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To Make the First Decision |
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2019-12-24 07:35 |
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Return for Revision |
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2019-12-24 07:35 |
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Revised |
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2019-12-24 07:52 |
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Second Decision |
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2020-01-11 10:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-01-15 00:45 |
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Articles in Press |
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2020-01-15 00:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-03-18 03:30 |
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Publish the Manuscript Online |
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2020-03-24 05:16 |
| ISSN |
1948-5182 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Reem Ghazali, Kosha J Mehta, SW Annie Bligh, Ihab Tewfik, Dahn Clemens and Vinood B Patel |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Vinood B Patel, FRSC, PhD, Reader (Associate Professor), School of Life Sciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, United Kingdom. v.b.patel@westminster.ac.uk |
| Key Words |
Non alcoholic fatty liver disease; Lipogenesis; Omega fatty acids; Mitochondrial dysfunction; Reactive oxygen species; Oxidative stress |
| Core Tip |
A high ratio of omega 6:3 fatty acids in the diet has been implicated in the develop-ment of non alcoholic fatty liver disease, a growing epidemic of major concern. The cellular pathology induced by such high ratios remains unknown. Here, we ob-served that in human hepatoma HepG2 (VL-17A) cells, high omega-6:omega-3 ratio reduced mitochondrial activity, increased triglyceride accumulation, elevated reac-tive oxygen species levels and interrupted several mitochondrial functions. Moreo-ver, the increased expression of stearoyl-CoA desaturase, decreased expression of peroxisome proliferator-activated receptor alpha and elevation in cannabinoid recep-tor-1 expression collectively lead to lipogenesis and lipotoxicity, which are key fea-tures of non alcoholic fatty liver disease development. |
| Publish Date |
2020-03-24 05:16 |
| Citation |
Ghazali R, Mehta KJ, Bligh SA, Tewfik I, Dahn Clemens D, Patel VB. High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells. World J Hepatol 2020; 12(3): 84-98 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i3/84.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i3.84 |
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