| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jian-Guo Gao, Mo-Sang Yu, Meng-Meng Zhang, Xue-Wei Gu, Yue Ren, Xin-Xin Zhou, Dong Chen, Tian-Lian Yan, You-Ming Li and Xi Jin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81770574 |
| National Natural Science Foundation of China (General Program) |
81600414 |
| National Natural Science Foundation of China (General Program) |
81600447 |
|
| Corresponding Author |
Xi Jin, PhD, Associate Chief Physician, Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Rd, Hangzhou 310003, Zhejiang Province, China. jxfl007@zju.edu.cn |
| Key Words |
Crohn’s disease; Adipose-derived mesenchymal stem cell; Intestinal epithelial cell; Wnt pathway; T cell; Inflammation |
| Core Tip |
The prevalence and mortality of Crohn’s disease (CD) have been increasing globally, including in areas of Asia that previously had low-incidence. We aimed to investigate the effect and explore potential mechanisms of adipose-derived mesenchymal stem cells (ADSCs) in a 2, 4, 6-trinitrobenzene sulfonic acid-induced rat model of CD. Our study for the first time provided evidence that the successfully isolated ADSCs showed therapeutic effects in CD through regulating intestinal epithelial cells proliferation, the Wnt signaling pathway and T cell immunity. |
| Publish Date |
2020-07-14 15:42 |
| Citation |
Gao JG, Yu MS, Zhang MM, Gu XW, Ren Y, Zhou XX, Chen D, Yan TL, Li YM, Jin X. Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity. World J Gastroenterol 2020; 26(26): 3750-3766 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i26/3750.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i26.3750 |
