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7/14/2020 3:42:19 PM | Browse: 430 | Download: 728
Publication Name World Journal of Gastroenterology
Manuscript ID 53595
Country/Territory China
Received
2019-12-27 06:13
Peer-Review Started
2019-12-25 06:59
To Make the First Decision
Return for Revision
2020-02-14 18:01
Revised
2020-05-14 05:39
Second Decision
2020-06-02 08:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-06-02 18:13
Articles in Press
2020-06-02 18:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-06-08 04:23
Typeset the Manuscript
2020-07-14 00:16
Publish the Manuscript Online
2020-07-14 15:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity
Manuscript Source Invited Manuscript
All Author List Jian-Guo Gao, Mo-Sang Yu, Meng-Meng Zhang, Xue-Wei Gu, Yue Ren, Xin-Xin Zhou, Dong Chen, Tian-Lian Yan, You-Ming Li and Xi Jin
ORCID
Author(s) ORCID Number
Jian-Guo Gao http://orcid.org/0000-0002-9414-5395
Mo-Sang Yu http://orcid.org/0000-0002-5614-0227
Meng-Meng Zhang http://orcid.org/0000-0002-5390-7947
Xue-Wei Gu http://orcid.org/0000-0002-8391-6182
Yue Ren http://orcid.org/0000-0001-9071-2738
Xin-Xin Zhou http://orcid.org/0000-0003-0183-6400
Dong Chen http://orcid.org/0000-0002-9581-8774
Tian-Lian Yan http://orcid.org/0000-0003-2322-5029
You-Ming Li http://orcid.org/0000-0001-9279-2903
Xi Jin http://orcid.org/0000-0001-9985-3035
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (General Program) 81770574
National Natural Science Foundation of China (General Program) 81600414
National Natural Science Foundation of China (General Program) 81600447
Corresponding Author Xi Jin, PhD, Associate Chief Physician, Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Rd, Hangzhou 310003, Zhejiang Province, China. jxfl007@zju.edu.cn
Key Words Crohn’s disease; Adipose-derived mesenchymal stem cell; Intestinal epithelial cell; Wnt pathway; T cell; Inflammation
Core Tip The prevalence and mortality of Crohn’s disease (CD) have been increasing globally, including in areas of Asia that previously had low-incidence. We aimed to investigate the effect and explore potential mechanisms of adipose-derived mesenchymal stem cells (ADSCs) in a 2, 4, 6-trinitrobenzene sulfonic acid-induced rat model of CD. Our study for the first time provided evidence that the successfully isolated ADSCs showed therapeutic effects in CD through regulating intestinal epithelial cells proliferation, the Wnt signaling pathway and T cell immunity.
Publish Date 2020-07-14 15:42
Citation Gao JG, Yu MS, Zhang MM, Gu XW, Ren Y, Zhou XX, Chen D, Yan TL, Li YM, Jin X. Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity. World J Gastroenterol 2020; 26(26): 3750-3766
URL https://www.wjgnet.com/1007-9327/full/v26/i26/3750.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i26.3750
Full Article (PDF) WJG-26-3750.pdf
Full Article (Word) WJG-26-3750.docx
Manuscript File 53595-Review_WangTQ.doc
Answering Reviewers 53595-Answering reviewers.pdf
Audio Core Tip 53595-Audio core tip.MP3
Biostatistics Review Certificate 53595-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53595-Conflict-of-interest statement.pdf
Copyright License Agreement 53595-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53595-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 53595-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 53595-Language certificate.pdf
Supplementary Material 53595-Supplementary material.pdf
Peer-review Report 53595-Peer-review(s).pdf
Scientific Misconduct Check 53595-Bing-Liu M-2.PNG
Scientific Misconduct Check 53595-Scientific misconduct check.pdf
Scientific Editor Work List 53595-Scientific editor work list.pdf