| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Observational Study |
| Article Title |
Cytokines predict the virological response in chronic hepatitis B patients receiving peginterferon alfa-2a therapy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Kang Fu, Jie Cao, Ning-Ning Mi, Chong-Fei Huang, Long Gao, Jin-Duo Zhang, Ping Yue, Bing Bai, Yan-Yan Lin and Wen-Bo Meng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81872036 |
| Talent Innovation and Entrepreneurship Plan of Lanzhou City Chengguan District |
2019RCCX0038 |
| Science and Technology Plan of Chengguan District of Lanzhou City |
2019JSXC0092 |
|
| Corresponding Author |
Wen-Bo Meng, MD, PhD, Chief Doctor, Director, Director, Professor, Special Minimally Invasive Surgery Department, The First Hospital of Lanzhou University, No. 1 Donggang West Road, Lanzhou 730000, Gansu Province, China. mengwb@lzu.edu.cn |
| Key Words |
Chronic hepatitis B; Peginterferon-alpha-2a; Cytokine/chemokine; CXCL9; Interferon-inducible protein 10; Thymus and activation-regulated chemokine |
| Core Tip |
Analyses of the changes in cytokine expression patterns during treatment help to understand the pathogenesis of chronic hepatitis B and predict treatment responses. We found that macrophage inflammatory protein 1d, CXCL9, CXCL6, interferon-inducible protein 10 and thymus and activation-regulated chemokine have predictive effects on interferon therapy. Therefore, further large and long-term follow up studies are needed to determine the predictive value of cytokines in chronic hepatitis B patients to receive Peginterferon-alpha-2a treatment. In addition, the differences in these factors between the response and non-response groups and their specific biological roles in hepatitis B virus infection require further investigation. |
| Publish Date |
2020-06-08 03:15 |
| Citation |
Fu WK, Cao J, Mi NN, Huang CF, Gao L, Zhang JD, Yue P, Bai B, Lin YY, Meng WB. Cytokines predict the virological response in chronic hepatitis B patients receiving peginterferon alfa-2a therapy. World J Clin Cases 2020; 8(11): 2255-2265 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i11/2255.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i11.2255 |
