Publication Name	World Journal of Gastroenterology
Manuscript ID	5364
Country	China

Received	2013-09-03 10:02
Peer-Review Started	2013-09-03 14:20
To Make the First Decision	2013-10-29 12:36
Return for Revision	2013-10-30 10:51
Revised
Second Decision	2014-01-08 18:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-08 18:32
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-02-28 20:37
Typeset the Manuscript	2014-03-28 14:15
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Death decoy receptor overexpression and increased malignancy risk in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Liang Zong, Ping Chen and Da-Xin Wang
Funding Agency and Grant Number
Corresponding Author	Liang Zong, MD, PhD, Department of Gastrointestinal Surgery, Su Bei People’s Hospital of Jiangsu Province, Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, Jiangsu Province, China. 250537471@qq.com
Key Words	Colorectal carcinoma; Human epidermal growth factor receptor 2; Death decoy receptor; Immunohistochemistry; Prognosis
Core Tip	Overexpression of the human epidermal growth factor receptor 2 (HER2) and death decoy receptor (DcR3) has been observed in clinical specimens of colorectal cancer, but their roles in prognosis remain unknown. In this systematic investigation of the immunohistochemistry staining patterns of HER2 and DcR3 in 300 clinical specimens, only DcR3 overexpression was identified as a potential prognostic marker of colorectal cancer. Specifically, DcR3 tumor-positive staining showed a strong statistical correlation with lymph node metastasis and poor overall survival. Moreover, HER2-positive patients with DcR3 overexpression had poorer overall survival than their DcR3-negative counterparts.
Publish Date	2014-04-17 13:27
Citation	Zong L, Chen P, Wang DX. Death decoy receptor overexpression and increased malignancy risk in colorectal cancer. World J Gastroenterol 2014; 20(15): 4440-4445
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4440.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4440

Full Article (PDF)	WJG-20-4440.pdf
Full Article (Word)	WJG-20-4440.doc
Manuscript File	5364-Review.docx
Answering Reviewers	5364-Answering reviewers.pdf
Copyright License Agreement	5364-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5364-Language certificate.pdf
Peer-review Report	5364-Peer review(s).pdf
Scientific Editor Work List	5364-Scientific editor work list.doc