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Articles Published Processes
4/24/2020 10:13:26 AM | Browse: 924 | Download: 1518
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Received |
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2019-12-30 07:05 |
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Peer-Review Started |
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2019-12-30 07:05 |
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To Make the First Decision |
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2020-02-23 08:39 |
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Return for Revision |
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2020-02-26 01:35 |
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Revised |
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2020-03-27 11:12 |
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Second Decision |
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2020-04-07 09:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-04-08 04:48 |
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Articles in Press |
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2020-04-08 04:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-04-11 10:04 |
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Typeset the Manuscript |
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2020-04-21 02:43 |
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Publish the Manuscript Online |
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2020-04-24 10:13 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Probiotic mixture VSL#3: An overview of basic and clinical studies in chronic diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fang-Shu Cheng, Dan Pan, Bing Chang, Min Jiang and Li-Xuan Sang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Innovative Talent Support Program of the Institution of Higher Learning in Liaoning Province |
2018-478 |
| Innovative Talents of Science and Technology Support Program of Young and Middle People of Shenyang |
RC170446 |
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| Corresponding Author |
Li-Xuan Sang, PhD, Assistant Professor, Chief Doctor, Department of Geriatrics, the First Affiliated Hospital, China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. sanglixuan2008@163.com |
| Key Words |
VSL#3; Intestinal barrier function; Chronic diseases; Intestinal microbial balance; Cytokines; Therapeutic use |
| Core Tip |
The imbalance of intestinal microbiota is one of the important factors in multiple diseases. Probiotics have a benefit on human health as live microorganisms that can positively regulate the intestinal microbial composition. One probiotic mixture, VSL#3, consisting of eight live bacterial strains plays an essential function in preventing and treating digestive systemic and other systemic diseases in animals and humans. There is increasing evidence that VSL#3 works by modulating intestinal barrier function. It is able to improve tight junction protein function and the composition of intestinal microbiota and regulate immune-related cytokine expression. This review seeks to provide an overview of the role of VSL#3 in various kinds of diseases and its potential for clinical use in the future. |
| Publish Date |
2020-04-24 10:13 |
| Citation |
Cheng FS, Pan D, Chang B, Jiang M, Sang LX. Probiotic mixture VSL#3: An overview of basic and clinical studies in chronic diseases. World J Clin Cases 2020; 8(8): 1361-1384 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i8/1361.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i8.1361 |
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