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Articles Published Processes
7/23/2020 5:00:01 AM | Browse: 821 | Download: 1456
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Received |
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2020-01-07 15:35 |
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Peer-Review Started |
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2019-12-31 10:03 |
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To Make the First Decision |
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2020-02-21 09:56 |
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Return for Revision |
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2020-02-27 12:04 |
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Revised |
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2020-05-06 21:14 |
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Second Decision |
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2020-05-15 10:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-17 01:29 |
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Articles in Press |
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2020-05-17 01:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-07-20 16:20 |
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Publish the Manuscript Online |
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2020-07-23 05:00 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Oxidative stress in alcohol-related liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Huey K Tan, Euan Yates, Kristen Lilly and Ashwin D Dhanda |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ashwin D Dhanda, BSc, MBChB, MRCP, PhD, Associate Professor, South West Liver Unit, University Hospitals Plymouth NHS Trust, Derriford Road Crownhill, Plymouth PL6 8DH, Devon, United Kingdom. ashwin.dhanda@plymouth.ac.uk |
| Key Words |
Alcohol-related liver disease; Alcoholic hepatitis; Oxidative stress; Reactive oxygen species; Antioxidants; Epigenetics |
| Core Tip |
Alcohol is a global health problem with alcohol-related liver disease forming a significant proportion of alcohol-attributable deaths. However, there are no effective treatments for alcohol-related liver disease. Oxidative stress plays multiple roles in disease pathogenesis, which if better understood may yield new therapeutic targets. Here, we review the current literature on how alcohol consumption leads to oxidative stress and how this results in hepatocyte apoptosis and necrosis through its contribution to mitochondrial stress, dysregulation of cell signalling pathways and epigenetic regulation. |
| Publish Date |
2020-07-23 05:00 |
| Citation |
Tan HK, Yates E, Lilly K, Dhanda AD. Oxidative stress in alcohol-related liver disease. World J Hepatol 2020; 12(7): 332-349 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i7/332.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i7.332 |
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