Publication Name	World Journal of Gastroenterology
Manuscript ID	5383
Country	China

Received	2013-09-04 16:25
Peer-Review Started	2013-09-05 08:38
First Decision by Editorial Office Director
Return for Revision	2014-01-20 12:48
Revised	2014-02-21 19:42
Publication Fee Transferred
Second Decision by Editor	2014-04-03 10:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-04-03 12:24
Articles in Press	2014-05-23 11:09
Edit the Manuscript by Language Editor	2014-04-22 21:11
Typeset the Manuscript	2014-06-05 18:09
Publish the Manuscript Online	2014-07-03 15:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Phasic study of intestinal homeostasis disruption in experimental intestinal obstruction
Manuscript Source	Invited Manuscript
All Author List	Xiang-Yang Yu, Chang-Lin Zou, Zhen-Li Zhou, Tao Shan, Dong-Hua Li and Nai-Qiang Cui
Funding Agency and Grant Number	Funding Agency Grant Number National Program on Key Basic Research Project 2009CB522703
Corresponding Author	Xiang-Yang Yu, MD, Department of Gastrointestinal Surgery, Nankai Hospital, Nankai District, No. 6 Changjiang Rd, Tianjin 300100, China. yxynankai@126.com
Key Words	Intestinal obstruction; Rabbit model; Homeostasis disruption; Intestinal epithelial cells; Intestinal microorganisms; Intestinal immune system
Core Tip	A controllable rabbit model of intestinal obstruction was established. This model demonstrated that intestinal obstruction (1) induced intestinal epithelial cell damage and reduction; (2) disrupted the balance of intestinal microorganisms by abnormal proliferation of pathogenic bacteria; and (3) disrupted the intestinal immune system, observed as a decrease in the number and area of Peyer’s patches, and alteration of CD4+ T cell number and CD4/CD8+ T cell ratio. Furthermore, the levels of ornithine decarboxylase activity and citrulline and claudin 1 expression could serve as indicators of intestinal epithelial cell damage.
Publish Date	2014-07-03 15:30
Citation	Yu XY, Zou CL, Zhou ZL, Shan T, Li DH, Cui NQ. Phasic study of intestinal homeostasis disruption in experimental intestinal obstruction. World J Gastroenterol 2014; 20(25): 8130-8138
URL	http://www.wjgnet.com/1007-9327/full/v20/i25/8130.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i25.8130

Full Article (PDF)	WJG-20-8130.pdf
Full Article (Word)	WJG-20-8130.doc
Manuscript File	5383-Review.docx
Answering Reviewers	5383-Answering reviewers.pdf
Copyright License Agreement	5383-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5383-Language certificate.pdf
Peer-review Report	5383-Peer reviews.pdf
Scientific Editor Work List	5383-Scientific editor work list.doc