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Articles Published Processes
6/16/2020 11:34:55 AM | Browse: 790 | Download: 1287
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Received |
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2020-01-07 18:05 |
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Peer-Review Started |
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2020-01-07 18:05 |
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To Make the First Decision |
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2020-02-21 08:09 |
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Return for Revision |
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2020-02-23 02:59 |
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Revised |
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2020-04-04 21:14 |
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Second Decision |
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2020-04-15 08:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-04-18 23:54 |
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Articles in Press |
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2020-04-18 23:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-06-11 01:24 |
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Publish the Manuscript Online |
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2020-06-16 11:34 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
P2X7 receptor antagonist recovers ileum myenteric neurons after experimental ulcerative colitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Roberta Figueiroa Souza, Mariá Munhoz Evangelinellis, Cristina Eusébio Mendes, Marta Righetti, Múcio Cevulla Silva Lourenço and Patricia Castelucci |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Foundation São Paulo Research |
2014/25927-2 |
| Foundation São Paulo Research |
2018/07862-1 |
| Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
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| Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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| Corresponding Author |
Patricia Castelucci, PhD, Associate Professor, Department of Anatomy, University of São Paulo, Lineu Prestes, 2415, São Paulo 05508-900, Brazil. pcastel@usp.br |
| Key Words |
P2X7 receptor; Brilliant blue G; Myenteric plexus; Experimental ulcerative colitis; Ileum; Chemical coding |
| Core Tip |
This work aims to analyze the effects of experimental ulcerative colitis (EUC) in ileum myenteric neurons immunoreactive (ir) for P2X7 receptor, neuronal nitric oxide synthase, choline acetyltransferase, HuC/D and enteric glial cells immunoreactive for glial fibrillary acidic protein. The animals were treated with P2X7 receptor antagonist, brilliant blue G (BBG). The results showed that the numbers of neuronal nitric oxide synthase-, choline acetyltransferase-, HuC/D-ir neurons and glial fibrillary acidic protein-ir glial cells were decreased in the EUC group and recovered in the animals treated with BBG. BBG treatment demonstrated that the P2X7 receptor may be a possible therapeutic target in the treatment of the EUC. |
| Publish Date |
2020-06-16 11:34 |
| Citation |
Souza RF, Evangelinellis MM, Mendes CE, Righetti M, Lourenço MCS, Castelucci P. P2X7 receptor antagonist recovers ileum myenteric neurons after experimental ulcerative colitis. World J Gastrointest Pathophysiol 2020; 11(4): 84-103 |
| URL |
https://www.wjgnet.com/2150-5330/full/v11/i4/84.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v11.i4.84 |
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