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6/16/2020 11:34:55 AM | Browse: 640 | Download: 717
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 54064
Country/Territory Brazil
Received
2020-01-07 18:05
Peer-Review Started
2020-01-07 18:05
To Make the First Decision
2020-02-21 08:09
Return for Revision
2020-02-23 02:59
Revised
2020-04-04 21:14
Second Decision
2020-04-15 08:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-04-18 23:54
Articles in Press
2020-04-18 23:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-06-11 01:24
Publish the Manuscript Online
2020-06-16 11:34
ISSN 2150-5330 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title P2X7 receptor antagonist recovers ileum myenteric neurons after experimental ulcerative colitis
Manuscript Source Invited Manuscript
All Author List Roberta Figueiroa Souza, Mariá Munhoz Evangelinellis, Cristina Eusébio Mendes, Marta Righetti, Múcio Cevulla Silva Lourenço and Patricia Castelucci
ORCID
Author(s) ORCID Number
Roberta Figueiroa Souza http://orcid.org/0000-0003-4380-6373
Mariá Munhoz Evangelinellis http://orcid.org/0000-0002-2594-437X
Cristina Eusébio Mendes http://orcid.org/0000-0003-3534-6282
Marta Righetti http://orcid.org/0000-0002-0963-9893
Múcio Cevulla Silva Lourenço http://orcid.org/0000-0002-3466-7976
Patricia Castelucci http://orcid.org/0000-0002-7475-5962
Funding Agency and Grant Number
Funding Agency Grant Number
Foundation São Paulo Research 2014/25927-2
Foundation São Paulo Research 2018/07862-1
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Corresponding Author Patricia Castelucci, PhD, Associate Professor, Department of Anatomy, University of São Paulo, Lineu Prestes, 2415, São Paulo 05508-900, Brazil. pcastel@usp.br
Key Words P2X7 receptor; Brilliant blue G; Myenteric plexus; Experimental ulcerative colitis; Ileum; Chemical coding
Core Tip This work aims to analyze the effects of experimental ulcerative colitis (EUC) in ileum myenteric neurons immunoreactive (ir) for P2X7 receptor, neuronal nitric oxide synthase, choline acetyltransferase, HuC/D and enteric glial cells immunoreactive for glial fibrillary acidic protein. The animals were treated with P2X7 receptor antagonist, brilliant blue G (BBG). The results showed that the numbers of neuronal nitric oxide synthase-, choline acetyltransferase-, HuC/D-ir neurons and glial fibrillary acidic protein-ir glial cells were decreased in the EUC group and recovered in the animals treated with BBG. BBG treatment demonstrated that the P2X7 receptor may be a possible therapeutic target in the treatment of the EUC.
Publish Date 2020-06-16 11:34
Citation Souza RF, Evangelinellis MM, Mendes CE, Righetti M, Lourenço MCS, Castelucci P. P2X7 receptor antagonist recovers ileum myenteric neurons after experimental ulcerative colitis. World J Gastrointest Pathophysiol 2020; 11(4): 84-103
URL https://www.wjgnet.com/2150-5330/full/v11/i4/84.htm
DOI https://dx.doi.org/10.4291/wjgp.v11.i4.84
Full Article (PDF) WJGP-11-84.pdf
Full Article (Word) WJGP-11-84.docx
The ARRIVE Guidelines 54064-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 54064-Review.docx
Answering Reviewers 54064-Answering reviewers.pdf
Audio Core Tip 54064-Audio core tip.m4a
Biostatistics Review Certificate 54064-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 54064-Conflict-of-interest statement.pdf
Copyright License Agreement 54064-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54064-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 54064-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 54064-Language certificate.pdf
Peer-review Report 54064-Peer-review(s).pdf
Scientific Misconduct Check 54064-Scientific misconduct check.pdf
Scientific Editor Work List 54064-Scientific editor work list.pdf