| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Fibrin sealant for esophageal anastomosis: A phase II study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yao-Bin Lin, Jian-Hua Fu, Yan Huang, Yi-Huai Hu, Kong-Jia Luo, Ke-Xi Wang, Amos Éla Bella, Dong-Rong Situ, Ji-Yang Chen, Ting Lin, Xavier B D’Journo, Nuria M Novoa, Alessandro Brunelli, Hiran C Fernando, Robert J Cerfolio, Mahmoud Ismail and Hong Yang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundamental Research Funds for the Central Universities |
17ykzd30 |
| National Natural Science Foundation of China |
81972614 |
| Guangdong Esophageal Cancer Institute Science and Technology Program |
M201601 |
| Health & Medical Collaborative Innovation Project of Guangzhou City, China |
201803040018 |
|
| Corresponding Author |
Hong Yang, MD, PhD, Associate Professor, Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, Guangdong Province, China. yanghong@sysucc.org.cn |
| Key Words |
Esophageal cancer; McKeown esophagectomy; Fibrin sealant; Anastomotic leakage; Postoperative complications; Prevention |
| Core Tip |
The application of fibrin sealant (FS) in esophageal surgery is an attractive therapeutic strategy to prevent anastomotic leakage. In this study, the efficacy and safety of FS were assessed in 57 patients with resectable esophageal or junctional cancer undergoing McKeown esophagectomy. Our findings showed that perioperative sealing with FS was safe and effective for preventing AL in patients with esophageal or junctional cancer, supporting further investigation in phase III trials and implementation in clinical practice. |
| Publish Date |
2020-06-15 08:19 |
| Citation |
Lin YB, JH, Huang Y, Hu YH, Luo KJ, Wang KX,Éla Bella A, Situ DR, Chen JY, Lin T, D’Journo XB, Novoa NM, Brunelli A, Fernando HC, Cerfolio RJ, Ismail M, Yang H; the AME Thoracic Surgery Collaborative Group. Fibrin sealant for esophageal anastomosis: A phase II study. World J Gastrointest Oncol 2020; 12(6): 651-662 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i6/651.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i6.651 |
