| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Fiorenza Ferrari, Elisa Scalzotto, Pasquale Esposito, Sara Samoni, Flavio Mistorigo, Lilia Maria Rizzo Topete, Massimo De Cal, Grazia Maria Virzì, Valentina Corradi, Rossella Torregrossa, Roberto Valle, Stefania Bianzina, Nadia Aspromonte, Matteo Floris, Alessandro Fontanelli, Alessandra Brendolani and Claudio Ronco |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Pasquale Esposito, MD, PhD, Doctor, Doctor, Professor, Department of Internal Medicine, Nephrology, Dialysis and Transplantation Clinics, Genoa University and IRCCS Policlinico San Martino, Viale Benedetto XV, Genova 16132, Italy. pasqualeesposito@hotmail.com |
| Key Words |
Cardiorenal syndrome type 1; Acute kidney injury; Biomarker; Neutrophil gelatinase-associated lipocalin; ; |
| Core Tip |
Renal and cardiac injuries are often interrelated, leading to high-risk clinical conditions. In this retrospective study, we evaluated the onset of acute kidney injury in 202 patients affected by acute heart disease [classified as cardiorenal syndrome-1 (CRS-1)], testing the potentiality of serum neutrophil gelatinase-associated lipocalin as a predictive marker of renal damage. Although the prevalence of CRS-1 in our population (27.2%) was consistent with that found in the literature, serum neutrophil gelatinase-associated lipocalin was not associated with CRS-1 development, probably as a consequence of the mild renal and cardiac injuries present in our study population. These data suggest that patient selection is crucial when considering the use of biomarkers. |
| Publish Date |
2020-04-30 15:27 |
| Citation |
Ferrari F, Scalzotto E, Esposito P, Samoni S, Mistrorigo F, Rizo Topete LM, De Cal M, Virzì GM, Corradi V, Torregrossa R, Valle R, Bianzina S, Aspromonte N, Floris M, Fontanelli A, Brendolan A, Ronco C. Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure. World J Clin Cases 2020; 8(9): 1600-1607 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i9/1600.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i9.1600 |
