Publication Name	World Journal of Hematology
Manuscript ID	5415
Country	United States

Received	2013-09-06 14:03
Peer-Review Started	2013-09-09 08:44
To Make the First Decision	2013-09-29 10:31
Return for Revision	2013-09-29 18:24
Revised	2013-10-06 09:17
Second Decision	2013-11-15 18:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-16 01:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-27 15:29
Publish the Manuscript Online	2014-02-19 14:03

ISSN	2218-6204 (online)
Open Access
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Category	Hematology
Manuscript Type	Review
Article Title	A concise, practical guide to diagnostic assessment for mast cell activation diseasecell activation disease
Manuscript Source	Invited Manuscript
All Author List	Lawrence B Afrin and Gerhard J Molderings
Funding Agency and Grant Number
Corresponding Author	Lawrence B Afrin, MD, BSB103, MSC635, Division of Hematology/Oncology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425-6350, United States. afrinl@musc.edu
Key Words	mast cell activation disease; mastocytosis; mast cell activation syndrome; mast cell mediators; tryptase; KIT mutations
Core Tip	Mast cell activation disease (MCAD) is characterized by accumulation of genetically altered mast cells and/or abnormal release of these cells’ mediators, affecting functions in potentially every organ system, often without causing abnormalities in routine laboratory or radiologic testing. Recent data suggest a high prevalence of MCAD. Thus, MCAD should be considered routinely in the differential diagnosis of patients with chronic multisystem polymorbidity of a generally inflammatory theme or patients in whom established diagnoses do not well account for the patient’s presentation of symptoms consistent with mast cell mediator release. Mediator testing can be challenging but typically is manageable. Diagnostic efforts are worthwhile, as diagnosis often leads to effective therapy.
Publish Date	2014-02-19 14:03
Citation	Afrin LB, Molderings GJ. A concise, practical guide to diagnostic assessment for mast cell activation disease. World J Hematol 2014; 3(1): 1-17
URL	http://www.wjgnet.com/2218-6204/full/v3/i1/1.htm
DOI	http://dx.doi.org/10.5315/wjh.v3.i1.

Manuscript File	5415-Review.docx
Answering Reviewers	5415-Answering reviewers.pdf
Copyright License Agreement	5415-Copyright assignment.pdf
Peer-review Report	5415-Peer review(s).pdf
Scientific Editor Work List	5415-Scientific editor work list.doc