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Articles Published Processes
7/13/2020 8:20:42 AM | Browse: 928 | Download: 1473
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Received |
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2020-01-14 21:18 |
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Peer-Review Started |
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2020-01-14 21:18 |
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To Make the First Decision |
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Return for Revision |
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2020-04-22 21:48 |
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Revised |
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2020-05-08 15:18 |
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Second Decision |
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2020-06-29 09:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-07-01 22:29 |
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Articles in Press |
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2020-07-01 22:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-07-10 10:20 |
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Publish the Manuscript Online |
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2020-07-13 08:20 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Oxysterols as promising small molecules for bone tissue engineering: Systematic review
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ethan Cottrill, Julianna Lazzari, Zach Pennington, Jeff Ehresman, Andrew Schilling, Naomi Dirckx, Nicholas Theodore, Daniel Sciubba and Timothy Witham |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ethan Cottrill, MSc, Research Scientist, Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, United States. ecottri1@jhmi.edu |
| Key Words |
Oxysterol; Bone tissue engineering; Critical-sized defect; Biomaterial; Orthopaedic surgery; Systematic review |
| Core Tip |
Here we present the first systematic review evaluating the utility of oxysterols for bone tissue engineering. Thirteen preclinical studies examining seven unique oxysterols were evaluated; all examined compounds were found to have statistically significant in vivo osteoinductive properties, with some showing dose-dependent effects. Importantly, eight studies found oxysterols to have similar osteoinductive properties to rhBMP-2 in treated animals. These effects are thought to occur through direct activation of Smoothened in the Hedgehog signaling pathway. Future clinical work is necessary to determine the exact therapeutic utility of these molecules in orthopaedic surgery patients. |
| Publish Date |
2020-07-13 08:20 |
| Citation |
Cottrill E, Lazzari J, Pennington Z, Ehresman J, Schilling A, Dirckx N, Theodore N, Sciubba D, Witham T. Oxysterols as promising small molecules for bone tissue engineering: Systematic review. World J Orthop 2020; 11(7): 328-344 |
| URL |
https://www.wjgnet.com/2218-5836/full/v11/i7/328.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v11.i7.328 |
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