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7/13/2020 8:20:42 AM | Browse: 783 | Download: 1023
Publication Name World Journal of Orthopedics
Manuscript ID 54156
Country/Territory United States
Received
2020-01-14 21:18
Peer-Review Started
2020-01-14 21:18
To Make the First Decision
Return for Revision
2020-04-22 21:48
Revised
2020-05-08 15:18
Second Decision
2020-06-29 09:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-01 22:29
Articles in Press
2020-07-01 22:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-07-10 10:20
Publish the Manuscript Online
2020-07-13 08:20
ISSN 2218-5836 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Systematic Reviews
Article Title Oxysterols as promising small molecules for bone tissue engineering: Systematic review
Manuscript Source Unsolicited Manuscript
All Author List Ethan Cottrill, Julianna Lazzari, Zach Pennington, Jeff Ehresman, Andrew Schilling, Naomi Dirckx, Nicholas Theodore, Daniel Sciubba and Timothy Witham
ORCID
Author(s) ORCID Number
Ethan Cottrill http://orcid.org/0000-0001-5991-7962
Julianna Lazzari http://orcid.org/0000-0002-0214-7239
Zach Pennington http://orcid.org/0000-0001-8012-860X
Jeff Ehresman http://orcid.org/0000-0002-8900-8935
Andrew Schilling http://orcid.org/0000-0003-1044-3780
Naomi Dirckx http://orcid.org/0000-0002-7109-8688
Nicholas Theodore http://orcid.org/0000-0001-5355-2683
Daniel Sciubba http://orcid.org/0000-0001-7604-434X
Timothy Witham http://orcid.org/0000-0002-9397-8344
Funding Agency and Grant Number
Corresponding Author Ethan Cottrill, MSc, Research Scientist, Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, United States. ecottri1@jhmi.edu
Key Words Oxysterol; Bone tissue engineering; Critical-sized defect; Biomaterial; Orthopaedic surgery; Systematic review
Core Tip Here we present the first systematic review evaluating the utility of oxysterols for bone tissue engineering. Thirteen preclinical studies examining seven unique oxysterols were evaluated; all examined compounds were found to have statistically significant in vivo osteoinductive properties, with some showing dose-dependent effects. Importantly, eight studies found oxysterols to have similar osteoinductive properties to rhBMP-2 in treated animals. These effects are thought to occur through direct activation of Smoothened in the Hedgehog signaling pathway. Future clinical work is necessary to determine the exact therapeutic utility of these molecules in orthopaedic surgery patients.
Publish Date 2020-07-13 08:20
Citation Cottrill E, Lazzari J, Pennington Z, Ehresman J, Schilling A, Dirckx N, Theodore N, Sciubba D, Witham T. Oxysterols as promising small molecules for bone tissue engineering: Systematic review. World J Orthop 2020; 11(7): 328-344
URL https://www.wjgnet.com/2218-5836/full/v11/i7/328.htm
DOI https://dx.doi.org/10.5312/wjo.v11.i7.328
Full Article (PDF) WJO-11-328.pdf
Full Article (Word) WJO-11-328.docx
Manuscript File 54156-Review.docx
Answering Reviewers 54156-Answering reviewers.pdf
Audio Core Tip 54156-Audio core tip.m4a
Biostatistics Review Certificate 54156-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 54156-Conflict-of-interest statement.pdf
Copyright License Agreement 54156-Copyright license agreement.pdf
Peer-review Report 54156-Peer-review(s).pdf
Scientific Misconduct Check 54156-Bing-Yu XQ-1.png
Scientific Misconduct Check 54156-Bing-Dou Y-2.png
Scientific Misconduct Check 54156-Scientific misconduct check.pdf
Scientific Editor Work List 54156-Scientific editor work list.pdf