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5/7/2020 5:03:30 AM | Browse: 1042 | Download: 1282
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Received |
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2020-01-20 17:36 |
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Peer-Review Started |
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2020-01-20 17:36 |
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To Make the First Decision |
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Return for Revision |
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2020-04-02 20:00 |
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Revised |
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2020-04-09 16:48 |
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Second Decision |
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2020-04-20 08:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-04-20 17:24 |
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Articles in Press |
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2020-04-20 17:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-04-29 08:58 |
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Publish the Manuscript Online |
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2020-05-07 05:03 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Angeliki Katsarou, Ioannis I Moustakas, Iryna Pyrina, Panagiotis Lembessis, Michael Koutsilieris and Antonios Chatzigeorgiou |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Deutsche Forschungsgemeinschaft |
CH 1862/2-1 and CH 1862/3-1 |
| Hellenic Association for the Study of the Liver |
396067872 |
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| Corresponding Author |
Antonios Chatzigeorgiou, BSc, MD, PhD, Assistant Professor, Department of Physiology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Athens 11527, Greece. achatzig@med.uoa.gr |
| Key Words |
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Hepatic stellate cells; Inflammation; Liver fibrosis; Toll-like receptors |
| Core Tip |
Non-alcoholic fatty liver disease is a frequent disorder in western countries with a wide range of histopathological findings, varying from simple steatosis to fibrosis or even cirrhosis. Metabolic dysregulation, principally during obesity, triggers chronic inflammation in the liver, defined as steatohepatitis that favors the development of fibrosis and likely cirrhosis and hepatocellular cancer. In this review we summarize and discuss the current literature regarding the principal inflammatory pathways involved in the pathogenesis of non-alcoholic fatty liver disease and progression to non-alcoholic steatohepatitis. |
| Publish Date |
2020-05-07 05:03 |
| Citation |
Katsarou A, Moustakas II, Pyrina I, Lembessis P, Koutsilieris M, Chatzigeorgiou A. Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease. World J Gastroenterol 2020; 26(17): 1993-2011 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i17/1993.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i17.1993 |
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