Publication Name	World Journal of Psychiatry
Manuscript ID	54331
Country	China

Received	2020-02-20 21:48
Peer-Review Started	2020-02-20 21:49
To Make the First Decision
Return for Revision	2020-09-21 18:35
Revised	2020-10-06 01:55
Second Decision	2020-11-02 09:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-11-05 19:33
Articles in Press	2020-11-05 19:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-11-17 11:41
Typeset the Manuscript	2020-12-07 01:27
Publish the Manuscript Online	2020-12-15 08:41

ISSN	2220-3206 (online)
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Category	Psychiatry
Manuscript Type	Basic Study
Article Title	Identification of key genes involved in post-traumatic stress disorder: Evidence from bioinformatics analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Yao-Yao Bian, Li-Li Yang, Bin Zhang, Wen Li, Zheng-Jun Li, Wen-Lin Li and Li Zeng
ORCID	Author(s) ORCID Number Yao-Yao Bian http://orcid.org/0000-0002-9968-2501 Li-Li Yang http://orcid.org/0000-0001-5220-3094 Bin Zhang http://orcid.org/0000-0002-2339-6349 Wen Li http://orcid.org/0000-0002-3975-3312 Zheng-Jun Li http://orcid.org/0000-0001-8208-3898 Wen-Lin Li http://orcid.org/0000-0002-7105-2743 Li Zeng http://orcid.org/0000-0002-9095-9439
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81603529 National Natural Science Foundation of China 81704084 National Natural Science Foundation of China 81673982 Natural Science Foundation of the Jiangsu Higher Education Institutions 16KJB360002 Advantages of the Nursing Discipline Project of Jiangsu Province 2019YSHL005 Jiangsu Government Scholarship for Overseas Studies China Scholarship Council 201908320373 Qing Lan Project 014000773/2018-00376
Corresponding Author	Li Zeng, MD, PhD, Academic Research, School of First Clinical Medicine, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. zengbingli@njucm.edu.cn
Key Words	Post-traumatic stress disorder; Differentially expressed genes; Key pathway; Gene-pathway co-expression; Bioinformatics analysis; Microarray
Core Tip	Post-traumatic stress disorder (PTSD) is an affective disorder that is exposed by trauma or stress directly or indirectly. The pathogenesis of PTSD is not entirely understood. The purpose of this study is to uncover the critical signatures and key pathways to elucidate the underlying mechanisms of PTSD at the molecular level. To address this issue, the closely related genes and the most enriched pathways were identified by using bioinformatics analysis, which was then validated by using basic study in an exploratory approach. Our results showed that a series of significantly expressed genes and relevant pathways might serve as potential biomarkers involved in the pathogenesis of PTSD.
Publish Date	2020-12-15 08:41
Citation	Bian YY, Yang LL, Zhang B, Li W, Li ZJ, Li WL, Zeng L. Identification of key genes involved in post-traumatic stress disorder: Evidence from bioinformatics analysis. World J Psychiatr 2020; 10(12): 286-298
URL	https://www.wjgnet.com/2220-3206/full/v10/i12/286.htm
DOI	https://dx.doi.org/10.5498/wjp.v10.i12.286

Full Article (PDF)	WJP-10-286.pdf
Full Article (Word)	WJP-10-286.docx
The ARRIVE Guidelines	54331-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	54331_Auto_Edited_WangTQ.docx
Answering Reviewers	54331-Answering reviewers.pdf
Audio Core Tip	54331-Audio core tip.m4a
Biostatistics Review Certificate	54331-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	54331-Conflict-of-interest statement.pdf
Copyright License Agreement	54331-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	54331-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	54331-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	54331-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	54331-Language certificate.pdf
Supplementary Material	54331-Supplementary material.pdf
Peer-review Report	54331-Peer-review(s).pdf
Scientific Misconduct Check	54331-Bing-Yan JP-1.png
Scientific Misconduct Check	54331-Bing-Chen XF-2.png
Scientific Misconduct Check	54331-Scientific misconduct check.pdf
Scientific Editor Work List	54331-Scientific editor work list.pdf
CrossCheck Report	54331-CrossCheck Report.pdf