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6/24/2020 7:33:17 AM | Browse: 638 | Download: 1414
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Received |
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2020-02-24 09:49 |
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Peer-Review Started |
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2020-02-24 09:49 |
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To Make the First Decision |
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Return for Revision |
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2020-03-27 19:01 |
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Revised |
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2020-05-09 07:33 |
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Second Decision |
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2020-05-18 10:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-18 17:52 |
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Articles in Press |
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2020-05-18 17:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-05-21 23:28 |
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Typeset the Manuscript |
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2020-06-19 03:19 |
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Publish the Manuscript Online |
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2020-06-24 07:33 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Observational Study |
| Article Title |
Gene testing for osteonecrosis of the femoral head in systemic lupus erythematosus using targeted next-generation sequencing: A pilot study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Sheng Sun, Qing-Rui Yang, Yan-Yan Bai, Nai-Wen Hu, Dong-Xia Liu and Cheng-Yong Qin |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Cheng-Yong Qin, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jing Wu road 324, Jinan 250021, Shandong Province, China. qinchengyongdaoshi@163.com |
| Key Words |
Single nucleotide variations; Osteonecrosis of the femoral head; Systemic lupus erythematosus; Nitric oxide synthase 3; Collagen type II alpha 1 chain; Complement C3d receptor 2 |
| Core Tip |
Genetic predisposition might play important roles in the onset of osteonecrosis of the femoral head (ONFH) in systemic lupus erythematosus (SLE). Some gene loci such as complement C3d receptor 2 (CR2), nitric oxide synthase 3 (NOS3), collagen type II alpha 1 chain (COL2A1), protein tyrosine phosphatase non-receptor type 22 (PTPN22) and transient receptor potential cation channel subfamily V member 4 (TRPV4) were reported to be involved in this process. We investigated whether the risk of ONFH in SLE is associated with single nucleotide variations (SNVs) in these five genes by using FastTarget and Illumina Miseq sequencing technologies in 49 cases. Six patients were confirmed to have low frequency SNVs, including one in NOS3, four in COL2A1 and one in CR2. The onset of ONFH in SLE might be associated with the identified SNVs in NOS3, COL2A1 and CR2. |
| Publish Date |
2020-06-24 07:33 |
| Citation |
Sun HS, Yang QR, Bai YY, Hu NW, Liu DX, Qin CY. Gene testing for osteonecrosis of the femoral head in systemic lupus erythematosus using targeted next-generation sequencing: A pilot study. World J Clin Cases 2020; 8(12): 2530-2541 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i12/2530.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i12.2530 |
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