| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Maspin subcellular expression in wild-type and mutant TP53 gastric cancers
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Simona Gurzu, Ioan Jung, Haruhiko Sugimura, Raluca Ioana Stefan-van Staden, Hidetaka Yamada, Hiroko Natsume, Yuji Iwashita, Rita Szodorai and Janos Szederjesi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Romanian National Authority for Scientific Research |
20 PCCF/2018 |
|
| Corresponding Author |
Simona Gurzu, MD, PhD, Chief Doctor, Director, Director, Full Professor, Research Fellow, Research Scientist, Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, 38 Gheorghe Marinescu Street, Targu Mureș 530193, Mureș, Romania. simonagurzu@yahoo.com |
| Key Words |
p53; TP53 gene; Maspin; Gastric cancer; Carcinoma; |
| Core Tip |
In this paper we tried to emphasize the possible prognostic role of TP53 status, in gastric cancer, and its relation with Maspin protease. For the first time in literature, we have proved that TP53 gene mutations in exon 7 might induce knockdown Maspin but wild type p53 can partialy restore nuclear Maspin expression and decrease the metastatic potential of gastric adenocarcinoma cells. |
| Publish Date |
2020-07-15 11:47 |
| Citation |
Gurzu S, Jung I, Sugimura H, Stefan-van Staden RI, Yamada H, Natsume H, Iwashita Y, Szodorai R, Szederjesi J. Maspin subcellular expression in wild-type and mutant TP53 gastric cancers. World J Gastrointest Oncol 2020; 12(7): 741-755 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i7/741.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i7.741 |
