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Articles Published Processes
11/26/2020 10:14:32 AM | Browse: 476 | Download: 788
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Received |
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2020-02-14 01:10 |
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Peer-Review Started |
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2020-02-14 01:10 |
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To Make the First Decision |
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Return for Revision |
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2020-09-11 20:34 |
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Revised |
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2020-09-20 08:04 |
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Second Decision |
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2020-09-25 09:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-25 19:23 |
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Articles in Press |
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2020-09-25 19:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-10-07 12:59 |
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Typeset the Manuscript |
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2020-11-19 07:48 |
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Publish the Manuscript Online |
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2020-11-26 10:14 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Acquired aplastic anemia: Is bystander insult to autologous hematopoiesis driven by immune surveillance against malignant cells?
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi-Chen Zhao, Xiao-Yun Sun, Bo Ju, Fan-Jun Meng and Hong-Guo Zhao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hong-Guo Zhao, MD, Chief Doctor, Professor, Department of Hematology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, Shandong Province, China. zhaohongguo6201@163.com |
| Key Words |
Acquired aplastic anemia; Bystander insult; Malignant clonal hematopoiesis; Immune surveillance; Antineoplastic; Gut inflammation |
| Core Tip |
We previously reported a severe aplastic anemia patient who had gotten an unexpected hematological response to treatment with intermittent gut-cleansing preparations. After his third recurrence, he was prescribed successive treatment with rifampicin, berberine and monthly administered gut-cleansing preparations for 4 mo, and he developed an erythroid proliferative neoplasma and an overwhelming enteropathy. We hereby make an extrapolation that, in a subgroup of aplastic anemia patients, the suppressed normal hematopoiesis may result from the bystander insult that is generated in response to the antigenic products of damaged hematopoietic cells, and may offer a protectively antineoplastic mechanism against malignant proliferation. |
| Publish Date |
2020-11-26 10:14 |
| Citation |
Zhao XC, Sun XY, Ju B, Meng FJ, Zhao HG. Acquired aplastic anemia: Is bystander insult to autologous hematopoiesis driven by immune surveillance against malignant cells? World J Stem Cells 2020; 12(11): 1429-1438 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i11/1429.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i11.1429 |
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