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5/7/2020 5:03:30 AM | Browse: 874 | Download: 1781
Publication Name World Journal of Gastroenterology
Manuscript ID 54586
Country Germany
Received
2020-02-11 04:06
Peer-Review Started
2020-02-11 04:07
To Make the First Decision
Return for Revision
2020-02-27 00:38
Revised
2020-03-26 11:15
Second Decision
2020-04-23 04:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2020-04-24 01:28
Articles in Press
2020-04-24 01:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-04-29 08:57
Publish the Manuscript Online
2020-05-07 05:03
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Clinical Trials Study
Article Title Assessment of hemostatic profile in patients with mild to advanced liver cirrhosis
Manuscript Source Unsolicited Manuscript
All Author List Elisabeth Hannah Adam, Madara Möhlmann, Eva Herrmann, Sonia Schneider, Kai Zacharowski, Stefan Zeuzem, Christian Friedrich Weber and Nina Weiler
ORCID
Author(s) ORCID Number
Elisabeth Hannah Adam http://orcid.org/0000-0001-5008-6293
Madara Möhlmann http://orcid.org/0000-0002-3931-6913
Eva Herrmann http://orcid.org/0000-0002-0662-6675
Sonia Schneider http://orcid.org/0000-0002-8971-9243
Kai Zacharowski http://orcid.org/0000-0002-0212-9110
Stefan Zeuzem http://orcid.org/0000-0002-0845-6833
Christian Friedrich Weber http://orcid.org/0000-0002-4501-5252
Nina Weiler http://orcid.org/0000-0001-5908-1413
Funding Agency and Grant Number
Corresponding Author Elisabeth Hannah Adam, MD, Attending Doctor, Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, Theodor-Stern Kai 7, Frankfurt 60590, Germany. elisabeth.adam@kgu.de
Key Words Liver cirrhosis; Model for end-stage liver disease; Coagulopathy; Multiple electrode aggregometry; Thrombelastometry; Hemostasis
Core Tip The results of our study show a moderately decreased platelet aggregation but no substantial impairment of the maximum clot firmness considering thrombelastometric results. Correlation analysis indicated that impedance aggregometric and thrombelastometric results did not correlate with model for end-stage liver disease score. Our data indicate that a potential coagulopathy in advanced liver cirrhosis may not be reflected by thrombelastometry or multiple electrode aggregometry as the underlying mechanisms may be beyond the platelet function of hemostasis. Rather, an individual assessment of a potential coagulopathy in patients with advanced disease is reasonable.
Publish Date 2020-05-07 05:03
Citation Adam EH, Möhlmann M, Herrmann E, Schneider S, Zacharowski K, Zeuzem S, Weber CF, Weiler N. Assessment of hemostatic profile in patients with mild to advanced liver cirrhosis. World J Gastroenterol 2020; 26(17): 2097-2110
URL https://www.wjgnet.com/1007-9327/full/v26/i17/2097.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i17.2097
Full Article (PDF) WJG-26-2097.pdf
Full Article (Word) WJG-26-2097.docx
Manuscript File 54586-Review.docx
Answering Reviewers 54586-Answering reviewers.pdf
Audio Core Tip 54586-Audio core tip.m4a
Biostatistics Review Certificate 54586-Biostatistics statement.pdf
Clinical Trial Registration Statement 54586-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 54586-Conflict-of-interest statement.pdf
Copyright License Agreement 54586-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 54586-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 54586-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 54586-Language certificate.pdf
Supplementary Material 54586-Supplementary material.pdf
Peer-review Report 54586-Peer-review(s).pdf
Scientific Misconduct Check 54586-Scientific misconduct check.pdf
Scientific Editor Work List 54586-Scientific editor work list.pdf
CrossCheck Report 54586-CrossCheck report.pdf