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Articles Published Processes
6/25/2020 10:09:17 AM | Browse: 827 | Download: 1578
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Received |
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2020-02-24 13:05 |
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Peer-Review Started |
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2020-02-24 13:06 |
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To Make the First Decision |
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Return for Revision |
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2020-04-25 21:47 |
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Revised |
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2020-05-09 14:13 |
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Second Decision |
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2020-05-19 08:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-20 06:10 |
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Articles in Press |
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2020-05-20 06:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-05-23 12:55 |
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Typeset the Manuscript |
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2020-06-23 14:55 |
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Publish the Manuscript Online |
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2020-06-25 10:09 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Energy metabolism in cancer stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xuan Zhu, Hui-Hui Chen, Chen-Yi Gao, Xin-Xin Zhang, Jing-Xin Jiang, Yi Zhang, Jun Fang, Feng Zhao and Zhi-Gang Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81502564 |
| National Natural Science Foundation of China |
81972598 |
| Natural Science Foundation of Zhejiang Province |
LY19H160004 |
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| Corresponding Author |
Zhi-Gang Chen, MD, PhD, Assistant Professor, Surgeon, Department of Breast Surgery, Zhejiang University School of Medicine, 88 Zheda Road, Hangzhou 310000, Zhejiang Province, China. chenzhigang@zju.edu.cn |
| Key Words |
Cancer stem cells; Differentiated cancer cells; Metabolic characteristics; Oxidative phosphorylation; Glycolysis; Tumor microenvironment |
| Core Tip |
Accumulating evidence indicates that the inadequacy of many treatments is due to their failure to target cancer stem cells (CSCs). Therefore, CSCs are a promising target for cancer treatment. Recently, it has been reported that CSCs exhibit a unique metabolic phenotype compared to normal cancer cells (non-CSCs), and CSCs can dynamically transform their metabolic state to favor glycolysis or oxidative metabolism. However, the mechanism of the metabolic plasticity of CSCs has not been fully elucidated, and existing evidence indicates that the metabolic phenotype of cancer cells is closely related to the tumor microenvironment (TME). In this article we summarized the metabolic characteristics of non-CSCs and CSCs, highlighted the mechanisms by which CSCs alter their energy metabolism via interactions with the surrounding TME, and discussed the potential therapeutic strategies to target energy metabolism in CSCs. |
| Publish Date |
2020-06-25 10:09 |
| Citation |
Zhu X, Chen HH, Gao CY, Zhang XX, Jiang JX, Zhang Y, Fang J, Zhao F, Chen ZG. Energy metabolism in cancer stem cells. World J Stem Cells 2020; 12(6): 448-461 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i6/448.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i6.448 |
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