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Articles Published Processes
8/26/2020 5:49:13 AM | Browse: 722 | Download: 1372
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Received |
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2020-02-25 13:43 |
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Peer-Review Started |
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2020-02-25 13:48 |
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To Make the First Decision |
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Return for Revision |
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2020-05-26 17:21 |
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Revised |
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2020-07-17 01:19 |
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Second Decision |
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2020-07-30 09:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-08-01 21:29 |
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Articles in Press |
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2020-08-01 21:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-08-23 12:48 |
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Publish the Manuscript Online |
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2020-08-26 05:49 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Toxicology |
| Manuscript Type |
Basic Study |
| Article Title |
Assessment of tobacco heating system 2.4 on osteogenic differentiation of mesenchymal stem cells and primary human osteoblasts compared to conventional cigarettes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Romina H Aspera-Werz, Sabrina Ehnert, Monja Müller, Sheng Zhu, Tao Chen, Weidong Weng, Johann Jacoby and Andreas K Nussler |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Andreas K Nussler, PhD, Professor, Department of Traumatology, BG Trauma Clinic, Siegfried Weller Institute for Trauma Research, Eberhard Karls Universität Tübingen, Schnarrenbergstraße 95, Tübingen 71076, Germany. andreas.nuessler@gmail.com |
| Key Words |
Primary human osteoblast; Cigarette smoke; Tobacco heating system; Mesenchymal stem cells; Electronic nicotine delivery systems; Bone |
| Core Tip |
Aqueous extracts (AE) generated with tobacco heating systems (THS) showed no differences in suspended particles compared to the cell culture medium. This finding supports previous studies demonstrating reduced levels of harmful constituents reported in THS AE in comparison to conventional cigarettes AE. The time to consume one unit (stick/cigarette) was longer for THS than for a conventional cigarette. The pH from both AE fractions was similar to the cell culture medium. Following a single exposure, THS AE was significantly less toxic to bone-forming cells and osteoprogenitor cells than conventional cigarettes AE. The cytotoxicity observed following THS exposure was associated with very high, non-physiological concentrations. No significant differences in cytotoxicity were observed between different flavors of THS AE. Moreover, THS AE displayed less impact on osteogenic differentiation of osteoprogenitor cells and the function of bone-forming cells when compared to conventional cigarettes AE. Finally, compared to conventional cigarettes AE, THS AE induced lower levels of oxidative stress due to the reduced level of harmful constituents, resulting in less damage to primary cilia structure and reduced impact on osteogenic differentiation. |
| Publish Date |
2020-08-26 05:49 |
| Citation |
Aspera-Werz RH, Ehnert S, Müller M, Zhu S, Chen T, Weng WD, Jacoby J, Nussler AK. Assessment of tobacco heating system 2.4 on osteogenic differentiation of mesenchymal stem cells and primary human osteoblasts compared to conventional cigarettes . World J Stem Cells 2020; 12(8): 841-856 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i8/841.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i8.841 |
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