| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Liver structural transformation after partial hepatectomy and repeated partial hepatectomy in rats: A renewed view on liver regeneration
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Keti Tsomaia, Leila Patarashvili, Nino Karumidze, Irakli Bebiashvili, Elza Azmaipharashvili, Irina Modebadze, Diana Dzidziguri, Marom Sareli, Sergey Gusev and Dimitri Kordzaia |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shota Rustaveli National Science Foundation of Georgia |
DP2016_22 |
|
| Corresponding Author |
Dimitri Kordzaia, DSc, MD, PhD, Dean, Professor, Clinical Anatomy and Operative Surgery, Ivane Javakhishvili Tbilisi State University, Beliashvili str. 78, Tbilisi 0159, Georgia. dimitri.kordzaia@tsu.ge |
| Key Words |
Partial hepatectomy; Repeated hepatectomy; Liver regeneration; Liver re-regeneration; Hepatocytes hypertrophy; Remodeling; Ploidy; Corrosion casts |
| Core Tip |
Liver regeneration after partial hepatectomy (PH) is based on both proliferation and hypertrophy of hepatocytes. These cells unite into remodeled lobules, the sizes of which vary widely. The microcirculation of the liver is also remodeled. At the same time, there is a suspicion that hyperplasia-hypertrophy and remod-eling do not apply to all hepatocytes and all lobules; it is also possible that, in parallel with remodeling, new lobules are formed. After repeated PH, liver re-generation is based on the same type of transformations, although their intensity is less. To fully evaluate the lobular and microcirculatory architecture of regen-erated liver after both, PH and repeated PH, it is necessary to investigate the ar-chitectonics of the initials of the biliary system. |
| Publish Date |
2020-07-21 13:23 |
| Citation |
Tsomaia K, Patarashvili L, Karumidze N, Bebiashvili I, Azmaipharashvili E, Modebadze I, Dzidziguri D, Sareli M, Gusev S, Kordzaia D. Liver structural transformation after partial hepatectomy and repeated partial hepatectomy in rats: A renewed view on liver regeneration. World J Gastroenterol 2020; 26(27): 3899-3916 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i27/3899.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i27.3899 |
