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Articles Published Processes
7/14/2020 3:42:19 PM | Browse: 1127 | Download: 2172
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Received |
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2020-02-26 11:29 |
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Peer-Review Started |
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2020-02-26 11:30 |
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First Decision by Editorial Office Director |
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2020-03-18 03:45 |
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Return for Revision |
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2020-03-18 03:45 |
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Revised |
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2020-05-18 03:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-06-24 08:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-06-25 04:53 |
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Articles in Press |
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2020-06-25 04:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-07-14 01:33 |
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Publish the Manuscript Online |
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2020-07-14 15:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sinem Cil Gonulcu, Betul Unal, Ibrahim Cumhur Bassorgun, Mualla Ozcan, Hasan Senol Coskun and Gulsum Ozlem Elpek |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Akdeniz University Research Foundation |
2017.04.0103.020 |
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| Corresponding Author |
Gulsum Ozlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical School, Dumlupınar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr |
| Key Words |
Colorectal adenomas; Colorectal cancer; Notch-1; Numb; Itch; Siah-1 |
| Core Tip |
This report describes a preliminary study to investigate Numb, Itch, and Siah-1 expression in colorectal tumors and to evaluate their relationship with Notch-1 expression and their roles in oncogenesis and prognosis. Our findings confirm the role of Notch-1 in colorectal carcinoma (CRC) and emphasize that loss of Numb, Itch, and Siah-1 expression is associated with carcinogenesis. Our data also indicate that Numb, Itch, and Siah-1 might be involved in the Notch-1 signaling pathway during CRC progression. Accordingly, these three proteins might be key in possible therapies targeting Notch-1 to treat colorectal carcinoma. |
| Publish Date |
2020-07-14 15:42 |
| Citation |
Gonulcu SC, Unal B, Bassorgun IC, Ozcan M, Coskun HS, Elpek GO. Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study. World J Gastroenterol 2020; 26(26): 3814-3833 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i26/3814.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i26.3814 |
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