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Articles Published Processes
6/21/2020 2:15:44 PM | Browse: 1252 | Download: 2871
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Received |
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2020-02-28 04:41 |
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Peer-Review Started |
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2020-02-28 04:45 |
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First Decision by Editorial Office Director |
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2020-04-22 22:54 |
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Return for Revision |
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2020-04-22 22:54 |
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Revised |
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2020-05-19 05:07 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-06-08 08:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-06-09 02:48 |
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Articles in Press |
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2020-06-09 02:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-06-19 09:01 |
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Publish the Manuscript Online |
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2020-06-21 14:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lakshini Y Herat, Natalie C Ward, Aaron L Magno, Elizabeth P Rakoczy, Marcio G Kiuchi, Markus P Schlaich and Vance B Matthews |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Royal Perth Hospital Medical Research Foundation |
VMMRF2018 |
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| Corresponding Author |
Vance B Matthews, BSc, PhD, Senior Research Fellow, School of Biomedical Sciences, Dobney Hypertension Centre, Royal Perth Hospital Unit, University of Western Australia, Level 3, MRF Building, Rear 50 Murray Street, Perth 6000, Australia. vance.matthews@uwa.edu.au |
| Key Words |
Sodium glucose co-transporter inhibitors; Sodium glucose co-transporter 2; Diabetes; Diabetic retinopathy; Mouse; Gut microbiota |
| Core Tip |
This novel study has shown that in a murine model of type 1 diabetes (T1D), is Sodium Glucose Co-transporter 2 (SGLT2) inhibition reduces serum succinate levels, increases short-chain fatty acid butyric acid levels and reduces norepinephrine content. These beneficial effects on T1D and its complications may highlight important mechanisms underlying the potential benefits of SGLT2 inhibition. |
| Publish Date |
2020-06-21 14:15 |
| Citation |
Herat LY, Ward N, Magno AL, Rakoczy EP, Kiuchi MG, Schlaich MP, Matthews VB. Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice. World J Gastroenterol 2020; 26(23): 3225-3235
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| URL |
https://www.wjgnet.com/1007-9327/full/v26/i23/3225.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i23.3225 |
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