| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Development of innovative tools for investigation of nutrient-gut interaction
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Wei-Kun Huang, Cong Xie, Richard L Young, Jiang-Bo Zhao, Heike Ebendorff-Heidepriem, Karen L Jones, Christopher K Rayner and Tong-Zhi Wu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Health and Medical Research Council (NHMRC) of Australia |
APP1147333 |
| National Nature Science Foundation of China |
81870561 |
| Hospital Research Foundation of Australia |
|
| Australian Research Council Centre of Excellence for Nanoscale BioPhotonics |
CE140100003 |
|
| Corresponding Author |
Tong-Zhi Wu, MD, PhD, Doctor, Doctor, Senior Research Fellow, Adelaide Medical School, Centre of Research Excellence in Translating Nutritional Science to Good Health, the University of Adelaide, Level 6 Adelaide Health and Medical Sciences (AHMS) building, North Terrace, Adelaide 5005, SA, Australia. tongzhi.wu@adelaide.edu.au |
| Key Words |
Nutrient-gut interaction; Metabolic disorders; Incretin hormones; Enteroendocrine cells; Enteroids; Intestinal intubation |
| Core Tip |
The development of platforms for investigating nutrient-gut interactions is critical to understanding how nutrients trigger the release of gut hormones and has the potential to yield novel targets for improved management of metabolic disorders. In addition to the use of endoscopic or surgical gut tissues or primary enteroendocrine cells, in vitro models now include enteroendocrine cell lines originating from rodent (STC-1 and GLUTag) or human (NCI-H716 and HuTo-80) intestinal tumours, and intestinal organoids differentiated from intestinal stem cells. The physiological relevance of these models has been challenged, but may be improved substantially by incorporating advanced biomedical techniques (e.g., microfluidic devices) into the culture system. These approaches have complemented clinical studies utilising intestinal intubation, often with integrated manometry and impedance recording, which have revealed gut region-specific responses to intraluminal contents. Newer clinical developments include the use of novel ingestible sensors. |
| Publish Date |
2020-07-07 14:50 |
| Citation |
Huang WK, Xie C, Young RL, Zhao JB, Ebendorff-Heidepriem H, Jones KL, Rayner CK, Wu TZ. Development of innovative tools for investigation of nutrient-gut interaction. World J Gastroenterol 2020; 26(25): 3562-3576 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i25/3562.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i25.3562 |
