Publication Name	World Journal of Meta-Analysis
Manuscript ID	5536
Country	United States

Received	2013-09-13 10:06
Peer-Review Started	2013-09-13 14:47
To Make the First Decision	2013-09-29 10:36
Return for Revision	2013-09-29 13:55
Revised	2013-10-01 02:08
Second Decision	2013-10-19 14:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-20 08:33
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-03 11:28
Publish the Manuscript Online	2013-12-19 19:04

ISSN	2308-3840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Meta-Analysis
Article Title	Preventing pediatric antibiotic-associated diarrhea and Clostridium difficile infections with probiotics: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Lynne V McFarland and Shan Goh
Funding Agency and Grant Number
Corresponding Author	Lynne V McFarland, PhD, Department of Medicinal Chemistry, University of Washington, Metropolitan Park West, 1100 Olive Way #1400, Seattle, WA 98101, United States. lvmcfarl@u.washington.edu
Key Words	Probiotics; Pediatric; Antibiotic-associated diarrhea; Clostridium difficile; Saccharomyces boulardii; Lactobacillus rhamnosus; Safety; Meta-analysis; Randomized clinical trials
Core Tip	A meta-analysis was conducted (1985-2013) for clinical trials testing probiotics for the prevention of pediatric antibiotic-associated diarrhea (AAD) or Clostridium difficile infections (CDI). Overall, probiotics significantly reduced the incidence of pediatric AAD (pooled from 22 trials RR = 0.42, 95%CI: 0.33-0.53) and significantly reduced pediatric CDI (pooled from five trials RR = 0.35, 95%CI: 0.13-0.92). Of the two strains with multiple trials, both significantly reduced pediatric AAD: Saccharomyces boulardii lyo (RR = 0.43, 95%CI: 0.32-0.60) and Lactobacillus rhamnosus GG (RR = 0.36, 95%CI: 0.19-0.69). There was no significant effect by type of antibiotic, or by duration or dose of probiotic.
Publish Date	2013-12-19 19:04
Citation	McFarland LV, Goh S. Preventing pediatric antibiotic-associated diarrhea and Clostridium difficile infections with probiotics: A meta-analysis. World J Meta-Anal 2013; 1(3): 102-120
URL	http://www.wjgnet.com/2308-3840/full/v1/i3/102.htm
DOI	http://dx.doi.org/10.13105/wjma.v1.i3.102

Full Article (PDF)	WJMA-1-102.pdf
Manuscript File	5536-Review.docx
Answering Reviewers	5536-Answering Reviewers.pdf
Copyright License Agreement	5536-Copyright Assignment.pdf
Peer-review Report	5536-Peer Review(s).pdf
Scientific Editor Work List	5536-Scientific editor work list.doc