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Articles Published Processes
9/4/2020 7:25:49 AM | Browse: 988 | Download: 2816
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Received |
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2020-03-28 12:35 |
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Peer-Review Started |
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2020-03-28 12:39 |
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First Decision by Editorial Office Director |
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2020-05-21 23:31 |
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Return for Revision |
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2020-05-21 23:31 |
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Revised |
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2020-07-21 06:10 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-08-11 08:19 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-08-12 07:26 |
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Articles in Press |
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2020-08-12 07:26 |
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Edit the Manuscript by Language Editor |
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2020-08-19 15:56 |
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Typeset the Manuscript |
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2020-09-03 04:14 |
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Publish the Manuscript Online |
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2020-09-04 07:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sena Bluemel, Yanhan Wang, Suhan Lee and Bernd Schnabl |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH |
R01 AA24726 |
| NIH |
U01 AA026939 |
| NIH |
P30 DK120515 |
| Swiss National Science Foundation |
P2SKP3_158649 |
| Swiss National Science Foundation |
P3400PB_171581 |
| Swiss National Science Foundation |
P3P3PB_171582 |
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| Corresponding Author |
Bernd Schnabl, MD, Professor, Department of Medicine, University of California San Diego, Biomedical Research Facility 2 (BRF2), Room 4A22, 9500 Gilman Drive, MC0063, La Jolla, CA 92093, United States. beschnabl@ucsd.edu |
| Key Words |
Tumor necrosis factor α receptor 1; Non-alcoholic steatohepatitis; Non-alcoholic fatty liver disease; Type 2 diabetes; Insulin resistance; Glucose intolerance |
| Core Tip |
We investigated the role of hepatocellular tumor necrosis factor receptor 1 (TNFR1) signaling in diet-induced non-alcoholic steatohepatitis (NASH) in mice with a deficiency for TNFR1 solely in hepatocytes. In contrast to most whole-body knock-out models, diet-induced NASH is not aggravated by hepatocellular TNFR1 deficiency in our study. However, insulin resistance was markedly improved, which strengthens the role of the liver in glucose homeostasis. |
| Publish Date |
2020-09-04 07:25 |
| Citation |
Bluemel S, Wang Y, Lee S, Schnabl B. Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice. World J Gastroenterol 2020; 26(33): 4933-4944
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| URL |
https://www.wjgnet.com/1007-9327/full/v26/i33/4933.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i33.4933 |
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