| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Herbal cake-partitioned moxibustion inhibits colonic autophagy in Crohn’s disease via signaling involving distinct classes of phosphatidylinositol 3-kinases
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Yuan Wang, Ji-Meng Zhao, Ci-Li Zhou, Han-Dan Zheng, Yan Huang, Min Zhao, Zhi-Ying Zhang, Lu-Yi Wu, Huan-Gan Wu and Hui-Rong Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Program of Shanghai Academic Research Leader |
No.17XD1403400 |
| National Natural Sciences Foundation of China |
No. 81574079, 81873374 |
| Three-year Action Plan Project of Shanghai Traditional Chinese Medicine Development |
ZY(2018-2020)-CCCX-2004-01 |
| Chinese Medicine Inheritance and Innovation "100 Million" Talent Project |
Qi Huang Scholar |
| Shanghai Rising-Star Program |
No. 16QA1403400 |
|
| Corresponding Author |
Hui-Rong Liu, MD, PhD, Doctor, Professor, Research Fellow, Key Laboratory of Acupuncture-Moxibustion and Immunology, Shanghai University of Traditional Chinese Medicine, No. 650 South Wanping Road, Xuhui District, Shanghai 201203, China. lhr_tcm@139.com |
| Key Words |
Crohn’s disease; Colon; Moxibustion; Macroautophagy; Immunity; Phosphatidylinositol 3-kinase signaling |
| Core Tip |
Here, we demonstrate that overactivation of colonic autophagy can be observed in a 2, 4, 6-Trinitrobenzenesulfonic acid (TNBS)-induced rat Crohn’s Disease (CD) model. Herbal cake-partitioned moxibustion (HM) ameliorates TNBS-induced inflammation and colon damage, facilitates the repair of colonic epithelial cells and inhibits colonic overactivated autophagy by activating the phosphatidylinositol 3-kinase Class I (PI3KC1)/protein kinase B akt-1 (Akt1)/mammalian target of rapamycin (mTOR) signaling pathway while inhibiting the class III phosphatidylinositol 3-kinase (PI3KC3/Vps34)-coiled-coil myosin-like BCL2-interacting protein (Beclin-1) complex in CD rats. |
| Publish Date |
2020-10-21 15:38 |
| Citation |
Wang SY, Zhao JM, Zhou CL, Zheng HD, Huang Y, Zhao M, Zhang ZY, Wu LY, Wu HG, Liu HR. Herbal cake-partitioned moxibustion inhibits colonic autophagy in Crohn’s disease via signaling involving distinct classes of phosphatidylinositol 3-kinases. World J Gastroenterol 2020; 26(39): 5997-6014 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i39/5997.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i39.5997 |
