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Articles Published Processes
9/22/2020 6:23:06 AM | Browse: 478 | Download: 984
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Received |
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2020-04-14 19:29 |
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Peer-Review Started |
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2020-04-14 19:29 |
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To Make the First Decision |
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Return for Revision |
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2020-04-29 21:50 |
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Revised |
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2020-05-13 17:29 |
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Second Decision |
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2020-09-02 12:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-09-02 18:20 |
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Articles in Press |
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2020-09-02 18:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-09-18 17:12 |
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Publish the Manuscript Online |
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2020-09-22 06:23 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Inflammatory niche: Mesenchymal stromal cell priming by soluble mediators
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aleksandra Jauković, Tamara Kukolj, Hristina Obradović, Ivana Okić-Đorđević, Slavko Mojsilović and Diana Bugarski |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Education, Science and Technological Development |
451-03-68/2020-14/200015 |
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| Corresponding Author |
Aleksandra Jauković, PhD, Associate Professor, Laboratory for Experimental Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, Dr. Subotića 4, PO BOX 102, Belgrade 11129, Serbia. aleksandra@imi.bg.ac.rs |
| Key Words |
Mesenchymal stem cells; Pro-inflammatory cytokines; Alarmins; Priming; Boosting therapeutic potential; |
| Core Tip |
The inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of mesenchymal stromal/stem cells (MSCs). This paper summarizes the data on how soluble factors in the inflammatory microenvironment, including pro-inflammatory cytokines secreted by immune cells and alarmins released by damaged cells, affect MSCs’ ability to regenerate tissue and modulate the inflammatory response. We also analyze data from in vitro and in vivo studies, which highlight the influence of these factors on the therapeutic potential of MSCs, thus providing an important background for the development of preconditioning strategies that might improve the outcomes of MSC-based cell therapies. |
| Publish Date |
2020-09-22 06:23 |
| Citation |
Jauković A, Kukolj T, Obradović H, Okić-Đorđević I, Mojsilović S, Bugarski D. Inflammatory niche: Mesenchymal stromal cell priming by soluble mediators. World J Stem Cells 2020; 12(9): 922-937 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i9/922.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i9.922 |
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