BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/24/2020 9:16:40 AM | Browse: 687 | Download: 1382
 |
Received |
|
2020-04-16 13:53 |
|
Peer-Review Started |
|
2020-04-16 13:53 |
|
First Decision by Editorial Office Director |
|
2020-07-25 21:00 |
|
Return for Revision |
|
2020-07-25 21:00 |
|
Revised |
|
2020-08-01 10:42 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2020-08-24 08:18 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2020-08-25 04:12 |
|
Articles in Press |
|
2020-08-25 04:12 |
|
Edit the Manuscript by Language Editor |
|
2020-08-30 19:40 |
|
Typeset the Manuscript |
|
2020-09-11 06:20 |
|
Publish the Manuscript Online |
|
2020-09-24 09:16 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Regulation of cytochrome c oxidase contributes to health and optimal life
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Bernhard Kadenbach |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Bernhard Kadenbach, DSc, PhD, Emeritus Professor, Department of Chemistry/Biochemistry, Fachbereich Chemie, Philipps-Universität Marburg, Marburg D-35043, Hessen, Germany. kadenbach@staff.uni-marburg.de |
| Key Words |
Cytochrome c oxidase; Regulation of respiration; Allosteric ATP-inhibition; NDUFA4; Reversible phosphorylation; Efficiency of ATP synthesis; Dimerization of cytochrome c oxidase |
| Core Tip |
This article describes the “allosteric ATP-inhibition of cytochrome c oxidase“, which prevents in all eukaryotic cells the formation of reactive oxygen species (ROS) under resting conditions by keeping the mitochondrial membrane potential ΔΨm at low values. Under stress – via increased calcium concentrations – this mechanism is switched off, accompanied by increased rates of ATP-synthesis with decreased efficiency and formation of deleterious ROS. A hypothesis is described in which NDUFA4 changes its position from complex I to cytochrome c oxidase when the metabolic state changes from rest to the excited state under stress. |
| Publish Date |
2020-09-24 09:16 |
| Citation |
Kadenbach B. Regulation of cytochrome c oxidase contributes to health and optimal life. World J Biol Chem 2020; 11(2): 52-61 |
| URL |
https://www.wjgnet.com/1949-8454/full/v11/i2/52.htm |
| DOI |
https://dx.doi.org/10.4331/wjbc.v11.i2.52 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
