BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/24/2020 9:16:40 AM | Browse: 423 | Download: 490
Publication Name World Journal of Biological Chemistry
Manuscript ID 56088
Country Germany
Received
2020-04-16 13:53
Peer-Review Started
2020-04-16 13:53
To Make the First Decision
Return for Revision
2020-07-25 21:00
Revised
2020-08-01 10:42
Second Decision
2020-08-24 08:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-08-25 04:12
Articles in Press
2020-08-25 04:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-08-30 19:40
Typeset the Manuscript
2020-09-11 06:20
Publish the Manuscript Online
2020-09-24 09:16
ISSN 1949-8454 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Review
Article Title Regulation of cytochrome c oxidase contributes to health and optimal life
Manuscript Source Invited Manuscript
All Author List Bernhard Kadenbach
ORCID
Author(s) ORCID Number
Bernhard Kadenbach http://orcid.org/0000-0002-0731-1667
Funding Agency and Grant Number
Corresponding Author Bernhard Kadenbach, DSc, PhD, Emeritus Professor, Department of Chemistry/Biochemistry, Fachbereich Chemie, Philipps-Universität Marburg, Marburg D-35043, Hessen, Germany. kadenbach@staff.uni-marburg.de
Key Words Cytochrome c oxidase; Regulation of respiration; Allosteric ATP-inhibition; NDUFA4; Reversible phosphorylation; Efficiency of ATP synthesis; Dimerization of cytochrome c oxidase
Core Tip This article describes the “allosteric ATP-inhibition of cytochrome c oxidase“, which prevents in all eukaryotic cells the formation of reactive oxygen species (ROS) under resting conditions by keeping the mitochondrial membrane potential ΔΨm at low values. Under stress – via increased calcium concentrations – this mechanism is switched off, accompanied by increased rates of ATP-synthesis with decreased efficiency and formation of deleterious ROS. A hypothesis is described in which NDUFA4 changes its position from complex I to cytochrome c oxidase when the metabolic state changes from rest to the excited state under stress.
Publish Date 2020-09-24 09:16
Citation Kadenbach B. Regulation of cytochrome c oxidase contributes to health and optimal life. World J Biol Chem 2020; 11(2): 52-61
URL https://www.wjgnet.com/1949-8454/full/v11/i2/52.htm
DOI https://dx.doi.org/10.4331/wjbc.v11.i2.52
Full Article (PDF) WJBC-11-52.pdf
Full Article (Word) WJBC-11-52.docx
Manuscript File 56088-Review-Filipodia.docx
Answering Reviewers 56088-Answering reviewers.pdf
Audio Core Tip 56088-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 56088-Conflict-of-interest statement.pdf
Copyright License Agreement 56088-Copyright-License-Agreement-revision.pdf
Peer-review Report 56088-Peer-review(s).pdf
Scientific Misconduct Check 56088-CrossCheck.png
Scientific Misconduct Check 56088-Bing-Gong ZM-2.png
Scientific Misconduct Check 56088-Scientific misconduct check.pdf
Scientific Editor Work List 56088-Scientific editor work list.pdf