Publication Name	World Journal of Biological Chemistry
Manuscript ID	56088
Country	Germany

Received	2020-04-16 13:53
Peer-Review Started	2020-04-16 13:53
To Make the First Decision
Return for Revision	2020-07-25 21:00
Revised	2020-08-01 10:42
Second Decision	2020-08-24 08:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-08-25 04:12
Articles in Press	2020-08-25 04:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-08-30 19:40
Typeset the Manuscript	2020-09-11 06:20
Publish the Manuscript Online	2020-09-24 09:16

ISSN	1949-8454 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Regulation of cytochrome c oxidase contributes to health and optimal life
Manuscript Source	Invited Manuscript
All Author List	Bernhard Kadenbach
ORCID	Author(s) ORCID Number Bernhard Kadenbach http://orcid.org/0000-0002-0731-1667
Funding Agency and Grant Number
Corresponding Author	Bernhard Kadenbach, DSc, PhD, Emeritus Professor, Department of Chemistry/Biochemistry, Fachbereich Chemie, Philipps-Universität Marburg, Marburg D-35043, Hessen, Germany. kadenbach@staff.uni-marburg.de
Key Words	Cytochrome c oxidase; Regulation of respiration; Allosteric ATP-inhibition; NDUFA4; Reversible phosphorylation; Efficiency of ATP synthesis; Dimerization of cytochrome c oxidase
Core Tip	This article describes the “allosteric ATP-inhibition of cytochrome c oxidase“, which prevents in all eukaryotic cells the formation of reactive oxygen species (ROS) under resting conditions by keeping the mitochondrial membrane potential ΔΨm at low values. Under stress – via increased calcium concentrations – this mechanism is switched off, accompanied by increased rates of ATP-synthesis with decreased efficiency and formation of deleterious ROS. A hypothesis is described in which NDUFA4 changes its position from complex I to cytochrome c oxidase when the metabolic state changes from rest to the excited state under stress.
Publish Date	2020-09-24 09:16
Citation	Kadenbach B. Regulation of cytochrome c oxidase contributes to health and optimal life. World J Biol Chem 2020; 11(2): 52-61
URL	https://www.wjgnet.com/1949-8454/full/v11/i2/52.htm
DOI	https://dx.doi.org/10.4331/wjbc.v11.i2.52

Full Article (PDF)	WJBC-11-52.pdf
Full Article (Word)	WJBC-11-52.docx
Manuscript File	56088-Review-Filipodia.docx
Answering Reviewers	56088-Answering reviewers.pdf
Audio Core Tip	56088-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	56088-Conflict-of-interest statement.pdf
Copyright License Agreement	56088-Copyright-License-Agreement-revision.pdf
Peer-review Report	56088-Peer-review(s).pdf
Scientific Misconduct Check	56088-CrossCheck.png
Scientific Misconduct Check	56088-Bing-Gong ZM-2.png
Scientific Misconduct Check	56088-Scientific misconduct check.pdf
Scientific Editor Work List	56088-Scientific editor work list.pdf
CrossCheck Report	56088-CrossCheck report.pdf