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Articles Published Processes
9/24/2020 9:16:40 AM | Browse: 519 | Download: 833
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Received |
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2020-04-16 13:53 |
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Peer-Review Started |
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2020-04-16 13:53 |
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To Make the First Decision |
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Return for Revision |
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2020-07-25 21:00 |
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Revised |
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2020-08-01 10:42 |
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Second Decision |
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2020-08-24 08:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-08-25 04:12 |
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Articles in Press |
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2020-08-25 04:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-08-30 19:40 |
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Typeset the Manuscript |
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2020-09-11 06:20 |
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Publish the Manuscript Online |
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2020-09-24 09:16 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Regulation of cytochrome c oxidase contributes to health and optimal life
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Bernhard Kadenbach |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Bernhard Kadenbach, DSc, PhD, Emeritus Professor, Department of Chemistry/Biochemistry, Fachbereich Chemie, Philipps-Universität Marburg, Marburg D-35043, Hessen, Germany. kadenbach@staff.uni-marburg.de |
| Key Words |
Cytochrome c oxidase; Regulation of respiration; Allosteric ATP-inhibition; NDUFA4; Reversible phosphorylation; Efficiency of ATP synthesis; Dimerization of cytochrome c oxidase |
| Core Tip |
This article describes the “allosteric ATP-inhibition of cytochrome c oxidase“, which prevents in all eukaryotic cells the formation of reactive oxygen species (ROS) under resting conditions by keeping the mitochondrial membrane potential ΔΨm at low values. Under stress – via increased calcium concentrations – this mechanism is switched off, accompanied by increased rates of ATP-synthesis with decreased efficiency and formation of deleterious ROS. A hypothesis is described in which NDUFA4 changes its position from complex I to cytochrome c oxidase when the metabolic state changes from rest to the excited state under stress. |
| Publish Date |
2020-09-24 09:16 |
| Citation |
Kadenbach B. Regulation of cytochrome c oxidase contributes to health and optimal life. World J Biol Chem 2020; 11(2): 52-61 |
| URL |
https://www.wjgnet.com/1949-8454/full/v11/i2/52.htm |
| DOI |
https://dx.doi.org/10.4331/wjbc.v11.i2.52 |
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