9/28/2020 1:45:47 AM | Browse: 788 | Download: 1723
| Publication Name | World Journal of Clinical Cases |
|---|---|
| Manuscript ID | 56102 |
| Country | China |
|
2020-04-19 16:10 | ||
|---|---|---|---|
|
2020-04-19 16:10 | ||
|
|||
|
2020-07-25 05:56 | ||
|
2020-08-08 15:42 | ||
|
2020-09-01 11:58 | ||
|
|||
|
2020-09-01 19:33 | ||
|
2020-09-01 19:33 | ||
|
|||
|
2020-09-14 06:15 | ||
|
2020-09-24 00:47 | ||
|
2020-09-28 01:45 |
| ISSN | 2307-8960 (online) |
|---|---|
| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Infectious Diseases | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Manuscript Type | Retrospective Study | ||||||||||||||||||||||||
| Article Title | Clinical application of combined detection of SARS-CoV-2-specific antibody and nucleic acid | ||||||||||||||||||||||||
| Manuscript Source | Invited Manuscript | ||||||||||||||||||||||||
| All Author List | Qing-Bin Meng, Jing-Jing Peng, Xin Wei, Jia-Yao Yang, Peng-Cheng Li, Zi-Wei Qu, Yong-Fen Xiong, Guang-Jiang Wu, Zhi-Min Hu, Jian-Chun Yu and Wen Su | ||||||||||||||||||||||||
| ORCID |
|
||||||||||||||||||||||||
| Funding Agency and Grant Number |
|
||||||||||||||||||||||||
| Corresponding Author | Wen Su, MD, PhD, Dean, Professor, Department of Science and Education, Wuhan Integrated TCM and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 215 Zhongshan Avenue, Wuhan 430022, Hubei Province, China. 501820747@qq.com | ||||||||||||||||||||||||
| Key Words | SARS-CoV-2; COVID-19; Nucleic acid detection; Immunoglobulin M; Immunoglobulin G; Diagnosis | ||||||||||||||||||||||||
| Core Tip | We retrospectively analyzed 652 suspected coronavirus disease 2019 (COVID-19) patients, and 206 non-COVID-19 patients to investigate the diagnostic value of severe acute respiratory syndrome coronavirus (SARS-CoV)-2 IgM/IgG and nucleic acid detection. We found that 237/652 (36.3%) suspected COVID-19 patients were positive for nucleic acid tests, 311 (47.7%) were positive for IgM, and 592 (90.8%) were positive for IgG. With reverse transcription polymerase chain reaction (RT-PCR) results as reference, the specificity, sensitivity, and accuracy of IgM/IgG combined tests for SARS-CoV-2 infection were 98.5%, 95.8%, and 97.1%, respectively. Our data indicates that serological IgM/IgG combined test can be used in combination with RT-PCR for diagnosis of SARS-CoV-2 infection. | ||||||||||||||||||||||||
| Publish Date | 2020-09-28 01:45 | ||||||||||||||||||||||||
| Citation | Meng QB, Peng JJ, Wei X, Yang JY, Li PC, Qu ZW, Xiong YF, Wu GJ, Hu ZM, Yu JC, Su W. Clinical application of combined detection of SARS-CoV-2-specific antibody and nucleic acid. World J Clin Cases 2020; 8(19): 4360-4369 | ||||||||||||||||||||||||
| URL | https://www.wjgnet.com/2307-8960/full/v8/i19/4360.htm | ||||||||||||||||||||||||
| DOI | https://dx.doi.org/10.12998/wjcc.v8.i19.4360 |
| Full Article (PDF) | WJCC-8-4360.pdf |
|---|---|
| Full Article (Word) | WJCC-8-4360.docx |
| Manuscript File | 56102-Review-Webster J.docx |
| Answering Reviewers | 56102-Answering reviewers.pdf |
| Audio Core Tip | 56102-Audio core tip.m4a |
| Biostatistics Review Certificate | 56102-Biostatistics statement.pdf |
| Conflict-of-Interest Disclosure Form | 56102-Conflict-of-interest statement.pdf |
| Copyright License Agreement | 56102-Copyright license agreement.pdf |
| Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) | 56102-Grant application form(s).pdf |
| Signed Informed Consent Form(s) or Document(s) | 56102-Informed consent statement.pdf |
| Institutional Review Board Approval Form or Document | 56102-Institutional review board statement.pdf |
| Non-Native Speakers of English Editing Certificate | 56102-Language certificate.pdf |
| Peer-review Report | 56102-Peer-review(s).pdf |
| Scientific Misconduct Check | 56102-Scientific misconduct check.pdf |
| Scientific Editor Work List | 56102-Scientific editor work list.pdf |
| CrossCheck Report | 56102-CrossCheck Report.pdf |