Publication Name	World Journal of Gastroenterology
Manuscript ID	5614
Country	Israel

Received	2013-09-17 11:59
Peer-Review Started	2013-09-17 17:44
To Make the First Decision	2013-09-27 16:28
Return for Revision	2013-09-30 14:19
Revised	2013-10-05 13:09
Second Decision	2013-11-04 18:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-05 11:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-14 10:12
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Ian M Carroll and Nitsan Maharshak
Funding Agency and Grant Number	Funding Agency Grant Number National institutes of health DK092330 (to Carroll IM)
Corresponding Author	Nitsan Maharshak, MD, Assistant Professor of Medicine, IBD Center, Department of Gastroenterology and Liver Disease, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, 6 Weizmann St., Tel Aviv 69643, Israel. nitsanm@tlvmc.gov.il
Key Words	Protease; Proteinase; Protease associated receptor; Enteric microbiota; Epithelial barrier
Core Tip	It is currently accepted that an enteric dysbiosis (alteration of the normal bacterial flora) is involved in the pathophysiology of inflammatory bowel diseases (IBD). One of the suggested mechanisms that ties an intestinal dysbiosis to the pathophysiology of IBD involves the release of enteric bacterial proteases that interact with protease activated receptors on epithelial cells, resulting in intestinal barrier dysfunction and exposure of the enteric immune system to luminal antigens. We have reviewed the literature that examined the role of microbial proteases and their enteric receptors in the pathogenesis of IBD, their suggested pathways of action, and discuss future therapeutic implications.
Publish Date	2013-12-18 09:53
Citation	Carroll IM, Maharshak N. Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications. World J Gastroenterol 2013; 19(43): 7531-7543
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7531.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7531

Full Article (PDF)	WJG-19-7531.pdf
Manuscript File	5614-Review.docx
Answering Reviewers	5614-Answering reviewers.pdf
Copyright License Agreement	5614-Copyright assignment.pdf
Peer-review Report	5614-Peer reviewer(s).pdf
Scientific Editor Work List	5614-Scientific editor work list.doc