Publication Name	World Journal of Gastroenterology
Manuscript ID	5634
Country	Japan

Received	2013-09-18 11:04
Peer-Review Started	2013-09-18 16:15
First Decision by Editorial Office Director
Return for Revision	2013-10-20 20:32
Revised	2013-11-07 02:04
Publication Fee Transferred
Second Decision by Editor	2014-01-06 17:31
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-01-06 19:07
Articles in Press
Edit the Manuscript by Language Editor	2014-03-03 17:25
Typeset the Manuscript	2014-04-01 16:55
Publish the Manuscript Online	2014-05-14 10:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy
Manuscript Source	Invited Manuscript
All Author List	Kaname Uno, Katsuaki Kato and Tooru Shimosegawa
Funding Agency and Grant Number
Corresponding Author	Katsuaki Kato, MD, PhD, Center of Cancer Screening, Miyagi Cancer Society, 5-7-30, Kamisugi, Aoba-ku, Sendai, Miyagi 980-0011, Japan. kkato@cat-v.ne.jp
Key Words	Toll like receptors; Helicobacter pylori; Gastric cancer; Pathogen-associated molecular patterns; Damage-associated molecular patterns
Core Tip	Toll-like receptors (TLRs) play important roles not only in the first line of defense against Helicobacter pylori (H. pylori), but also in gastric carcinogenesis. TLR signaling initiated by pathogen-associated molecular patterns of H. pylori consequently works to establish antigen-specific acquired immune responses. Simultaneously, damage-associated molecular patterns produced by chronic inflammation may contribute to gastric cancer development. A better understanding of TLRs will provide new insights into new diagnostic/predictive biomarkers and therapeutic targets for H. pylori-associated gastric cancer.
Publish Date	2014-05-14 10:58
Citation	Uno K, Kato K, Shimosegawa T. Novel role of Toll-like receptors in Helicobacter pylori - induced gastric malignancy. World J Gastroenterol 2014; 20(18): 5244-5251
URL	http://www.wjgnet.com/1007-9327/full/v20/i18/5244.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i18.5244

Full Article (PDF)	WJG-20-5244.pdf
Full Article (Word)	WJG-20-5244.doc
Manuscript File	5634-Review.docx
Answering Reviewers	5634-Answering reviewers.pdf
Copyright License Agreement	5634-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5634-Language certificate.docx
Peer-review Report	5634-Peer reviewer(s).pdf
Scientific Editor Work List	5634-Scientific editor work list.doc